| No variation of physical performance and perceived exertion after adrenal gland stimulation by synthetic ACTH (Synacthen) in cyclists. | |
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MedLine Citation:
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PMID: 18584198 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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There is anecdotal evidence that athletes use the banned substance Synacthen because of its perceived benefit with its associated rise in cortisol. To test the performance-enhancing effects of Synacthen, eight trained cyclists completed two, 2-day exercise sessions separated by 7-10 days. On the first day of each 2-day exercise session, subjects received either Synacthen (0.25 mg, TX) or placebo (PLA) injection. Performance was assessed by a 20-km time trial (TT) after a 90-min fatigue period on day 1 and without the fatiguing protocol on day 2. Plasma androgens and ACTH concentrations were measured during the exercise bouts as well as the rate of perceived exertion (RPE). Spot urines were analyzed for androgens and glucocorticoids quantification. Basal plasma hormones did not differ significantly between PLA and TX groups before and 24 h after the IM injection (P > 0.05). After TX injection, ACTH peaked at 30 min and hormone profiles were significantly different compared to the PLA trial (P < 0.001). RPE increased significantly in both groups as the exercise sessions progressed (P < 0.001) but was not influenced by treatment. The time to completion of the TT was not affected on both days by Synacthen treatment. In the present study, a single IM injection of synthetic ACTH did not improve either acute or subsequent cycling performance and did not influence perceived exertion. The investigated urinary hormones did not vary after treatment, reinforcing the difficulty for ACTH abuse detection. |
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Authors:
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Norbert Baume; Graeme Steel; Tony Edwards; Eric Thorstensen; Benjamin F Miller |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't Date: 2008-06-27 |
Journal Detail:
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Title: European journal of applied physiology Volume: 104 ISSN: 1439-6319 ISO Abbreviation: Eur. J. Appl. Physiol. Publication Date: 2008 Nov |
Date Detail:
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Created Date: 2008-10-07 Completed Date: 2008-12-18 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100954790 Medline TA: Eur J Appl Physiol Country: Germany |
Other Details:
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Languages: eng Pagination: 589-600 Citation Subset: IM |
Affiliation:
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Department of Sport and Exercise Science, Tamaki Campus, The University of Auckland, Auckland, New Zealand. norbert.baume@chuv.ch |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adrenal Glands
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drug effects*,
physiology Adrenocorticotropic Hormone / blood, pharmacology* Adult Athletic Performance / physiology* Bicycling / physiology* Cross-Over Studies Dehydroepiandrosterone / blood Double-Blind Method Glucocorticoids / blood Glucuronides / urine Heart Rate / drug effects, physiology Humans Hydrocortisone / blood Male Physical Exertion / physiology* Testosterone / blood |
| Chemical | |
Reg. No./Substance:
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0/Glucocorticoids; 0/Glucuronides; 50-23-7/Hydrocortisone; 53-43-0/Dehydroepiandrosterone; 58-22-0/Testosterone; 9002-60-2/Adrenocorticotropic Hormone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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