| No unexpected adverse events and biochemical side effects of olanzapine as adjunct treatment in adolescent girls with eating disorders. | |
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MedLine Citation:
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PMID: 21663424 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Abstract Objective: Olanzapine has been recently tried to relieve anxiety and hyperactivity in adolescents with eating disorders (EDs). Presently, the side effects of the drug have been evaluated. Method: Forty-seven adolescents with EDs were followed up by repeated blood sampling before, during, and at 3 months after medication with olanzapine. Results: Olanzapine medication was discontinued in three patients because of galactorrhea, seizures, and raised liver enzyme activities, respectively. There was a normalization of glucose, insulin, and lipid profiles during treatment, which was related to weight gain and resumption of menstruations but not to medication. Increases in thyroid-stimulating hormone and prolactin were related to olanzapine medication and comedication with selective serotonine reuptake inhibitors. Three months after discontinuing medication, there were no persisting biochemical effects. Conclusion: The side effects observed were those previously described for olanzapine. Most biochemical changes were related to weight (change) and amenorrhea and not to medication. Placebo-controlled studies are needed to investigate the efficacy of olanzapine in adolescents with EDs. |
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Authors:
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Ingemar Swenne; Agneta Rosling |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of child and adolescent psychopharmacology Volume: 21 ISSN: 1557-8992 ISO Abbreviation: J Child Adolesc Psychopharmacol Publication Date: 2011 Jun |
Date Detail:
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Created Date: 2011-06-13 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9105358 Medline TA: J Child Adolesc Psychopharmacol Country: United States |
Other Details:
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Languages: eng Pagination: 221-7 Citation Subset: IM |
Affiliation:
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1 Department of Women's and Children's Health, Uppsala University Children's Hospital , Uppsala, Sweden . |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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