| No synergistic effect of mesenchymal stem cells and exercise on functional recovery following sciatic nerve transection. | |
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MedLine Citation:
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PMID: 20626995 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The present study examined whether transplantation of mesenchymal stem cells (MSCs) in combination with exercise would have synergistic effects leading to functional recovery that is greater than exercise alone. Sprague-Dawley rats received a sciatic nerve transection and were divided into four groups: denervated (control), denervated + exercise (control+Ex), denervated + MSC transplantation (MSC), and denervated + MSC transplantation + exercise (MSC+Ex). A volume of 1 x 105 of MSCs was injected into the lesion site in the MSC-treated groups, and culture medium in the control animals. Twelve hours after surgery, a swimming exercise regime was begun: 30 minutes/day for seven days in the MSC+Ex and control+Ex groups. Functional assessments including sciatic function index (SFI), vertical locomotor activity (VA), ankle activity (AA), and electrophysiological studies were performed to monitor the functional recovery. Histological analysis was performed to assess nerve continuity and myelination. No significant differences in SFI, VA, AA and electrophysiological studies were found between the MSC+Ex and control+Ex groups. Also, a morphological study revealed prominent axonal degeneration in the injured nerves of all animals. The results revealed that any synergistic effect of MSC transplantation on functional recovery of swimming exercise-treated transected nerve that may have existed was negligible. |
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Authors:
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John Wang; Chen-Chia Yang; Shyh-Chan Chen; Yueh-Ling Hsieh |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Functional neurology Volume: 25 ISSN: 0393-5264 ISO Abbreviation: Funct. Neurol. Publication Date: 2010 Jan-Mar |
Date Detail:
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Created Date: 2010-07-14 Completed Date: 2010-08-31 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8707746 Medline TA: Funct Neurol Country: Italy |
Other Details:
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Languages: eng Pagination: 33-43 Citation Subset: IM |
Affiliation:
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Department of Pathology and Laboratory Medicine, Taichung Veterans General Hospital, Taichung, Taiwan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Behavior, Animal Disease Models, Animal Male Mesenchymal Stem Cell Transplantation / methods* Motor Activity Neural Conduction / physiology Physical Conditioning, Animal / methods* Rats Rats, Sprague-Dawley Recovery of Function / physiology* Sciatic Neuropathy / rehabilitation*, surgery* Swimming / physiology |
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