Document Detail


No synergistic effect of mesenchymal stem cells and exercise on functional recovery following sciatic nerve transection.
MedLine Citation:
PMID:  20626995     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The present study examined whether transplantation of mesenchymal stem cells (MSCs) in combination with exercise would have synergistic effects leading to functional recovery that is greater than exercise alone. Sprague-Dawley rats received a sciatic nerve transection and were divided into four groups: denervated (control), denervated + exercise (control+Ex), denervated + MSC transplantation (MSC), and denervated + MSC transplantation + exercise (MSC+Ex). A volume of 1 x 105 of MSCs was injected into the lesion site in the MSC-treated groups, and culture medium in the control animals. Twelve hours after surgery, a swimming exercise regime was begun: 30 minutes/day for seven days in the MSC+Ex and control+Ex groups. Functional assessments including sciatic function index (SFI), vertical locomotor activity (VA), ankle activity (AA), and electrophysiological studies were performed to monitor the functional recovery. Histological analysis was performed to assess nerve continuity and myelination. No significant differences in SFI, VA, AA and electrophysiological studies were found between the MSC+Ex and control+Ex groups. Also, a morphological study revealed prominent axonal degeneration in the injured nerves of all animals. The results revealed that any synergistic effect of MSC transplantation on functional recovery of swimming exercise-treated transected nerve that may have existed was negligible.
Authors:
John Wang; Chen-Chia Yang; Shyh-Chan Chen; Yueh-Ling Hsieh
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Functional neurology     Volume:  25     ISSN:  0393-5264     ISO Abbreviation:  Funct. Neurol.     Publication Date:    2010 Jan-Mar
Date Detail:
Created Date:  2010-07-14     Completed Date:  2010-08-31     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8707746     Medline TA:  Funct Neurol     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  33-43     Citation Subset:  IM    
Affiliation:
Department of Pathology and Laboratory Medicine, Taichung Veterans General Hospital, Taichung, Taiwan.
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MeSH Terms
Descriptor/Qualifier:
Animals
Behavior, Animal
Disease Models, Animal
Male
Mesenchymal Stem Cell Transplantation / methods*
Motor Activity
Neural Conduction / physiology
Physical Conditioning, Animal / methods*
Rats
Rats, Sprague-Dawley
Recovery of Function / physiology*
Sciatic Neuropathy / rehabilitation*,  surgery*
Swimming / physiology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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