Document Detail

No significant association between prenatal exposure poliovirus epidemics and psychosis.
MedLine Citation:
PMID:  12060186     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To examine the association between prenatal exposure to poliovirus infection and later development of schizophrenia or affective psychosis in a Southern Hemisphere psychiatric register. METHODS: We calculated rates of poliomyelitis cases per 10 000 background population and rates for schizophrenia(n = 6078) and affective psychosis (n = 3707)per 10 000 births for the period 1930-1964. Empirically weighted regression was used to measure the association between a given psychosis birth-rate and a poliomyelitis epidemic during gestation. RESULTS: There was no statistically significant association between exposure to a poliomyelitis epidemic during gestation and subsequent development of schizophrenia or affective psychosis. CONCLUSIONS: The lack of a consistent statistically significant association between poliovirus epidemics and schizophrenia suggests that either poliovirus may have a small effect which is only detectable with large data-sets and/or the effect may be modified by location. Further investigation of such inconsistencies may help elucidate candidate risk-modifying factors for schizophrenia.
Matthew Cahill; David Chant; Joy Welham; John McGrath
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Australian and New Zealand journal of psychiatry     Volume:  36     ISSN:  0004-8674     ISO Abbreviation:  Aust N Z J Psychiatry     Publication Date:  2002 Jun 
Date Detail:
Created Date:  2002-06-12     Completed Date:  2002-12-18     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0111052     Medline TA:  Aust N Z J Psychiatry     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  373-5     Citation Subset:  IM    
Queensland Centre for Schizophrenia Research, Wolston Park Hospital, Wacol, Australia.
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MeSH Terms
Affective Disorders, Psychotic / etiology*
Poliomyelitis / complications*
Prenatal Exposure Delayed Effects*
Schizophrenia / etiology*

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