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No significant association between p53 codon 72 Arg/Pro polymorphism and risk of oral cancer.
MedLine Citation:
PMID:  23192640     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
The genetic polymorphism of p53 codon 72 Arg/Pro has been implicated in oral cancer risk, but the results of previous studies remain controversial and ambiguous. To estimate the effect of the p53 codon 72 Arg/Pro polymorphism on the risk of oral cancer, a meta-analysis was performed. Based on a comprehensive search in PubMed, Embase, Web of Science, and China National Knowledge Infrastructure (CNKI) databases, we identified all available publications assessing the association between p53 codon 72 Arg/Pro polymorphism and oral cancer risk. The pooled odds ratio (OR) with its corresponding 95 % confidence interval (CI) was calculated to assess the association. Subgroup analyses by ethnicity and study quality were performed to further identify the correlation. Totally, 17 studies with 2,975 cases and 3,413 controls were included into this meta-analysis. There was no statistically significant association between the p53 codon 72 Arg/Pro polymorphism and oral cancer risk in all genetic contrast models (OR(Pro allele vs. Arg allele) = 1.05, 95 % CI 0.94-1.18, P(OR) = 0.379; OR(Pro/Pro vs. Arg/Arg) = 1.11, 95 % CI 0.89-1.40, P(OR) = 0.356; OR(Pro/Arg vs. Arg/Arg) = 1.10, 95 % CI 0.93-1.30, P(OR) = 0.256; OR(Pro/Arg + Pro/Pro vs. Arg/Arg) = 1.10, 95 % CI 0.93-1.31, P(OR) = 0.263; and OR(Pro/Pro vs. Arg/Arg + Pro/Arg) = 1.03, 95 % CI 0.90-1.18, P(OR) = 0.647). In the subgroup analysis of high-quality studies, we failed to find the susceptibility of p53 codon 72 Arg/Pro polymorphism to oral cancer. Moreover, the results were similar among Asians, Caucasians, and mixed populations when stratifying by ethnicity. Sensitivity analysis further confirmed the stability of the results. The present meta-analysis of currently available data shows no association between the p53 codon 72 Arg/Pro polymorphism and oral cancer risk.
Authors:
Ning Jiang; Jie Pan; Lei Wang; Yin-Zhong Duan
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-11-29
Journal Detail:
Title:  Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine     Volume:  -     ISSN:  1423-0380     ISO Abbreviation:  Tumour Biol.     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-29     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8409922     Medline TA:  Tumour Biol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Orthodontics, School of Stomatology, The Fourth Military Medical University, No. 145 West Changle Road, Xi'an, 710032, Shaanxi Province, People's Republic of China.
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