Document Detail

No significant association between the XRCC3 Thr241Met polymorphism and lung cancer risk: a meta-analysis.
MedLine Citation:
PMID:  23300009     Owner:  NLM     Status:  Publisher    
The development of lung cancer is significantly associated with genetic susceptibility. Findings from previous individual studies regarding the effect of X-ray repair cross-complementing group 3 Thr241Met (XRCC3 Thr241Met) polymorphism on lung cancer risk remained conflicting and inconclusive. Thus, a meta-analysis of previous relevant studies was performed to estimate this effect more precisely and to shed some light on the contradictory findings. The pooled odds ratios (ORs) with the corresponding 95 % confidence intervals (95 % CIs) were calculated to assess the correlation of XRCC3 Thr241Met polymorphism with lung cancer susceptibility. Stratified analysis according to ethnicity and sensitivity analysis was both conducted for further confirmation. Seventeen independent case-control studies involving 12,610 subjects totally were included into this meta-analysis. Overall, meta-analysis of total included studies showed that the XRCC3 Thr241Met polymorphism was not associated with risk of lung cancer in all genetic contrast models (OR(Met allele vs. Thr allele) = 1.01, 95 % CI 0.91-1.13, P (OR) = 0.810; OR(Met/Met vs. Thr/Thr) = 1.16, 95 % CI 0.88-1.54, P (OR) = 0.281; OR(Thr/Met vs. Thr/Thr) = 0.95, 95 % CI 0.86-1.04, P (OR) = 0.240; OR(Met/Met + Thr/Met vs. Thr/Thr) = 0.97, 95 % CI 0.89-1.06, P (OR) = 0.538; OR(Met/Met vs. Thr/Thr + Thr/Met) = 1.18, 95 % CI 0.91-1.52, P (OR) = 0.204). Stratified analyses in Asians and Caucasians showed similar results. Sensitivity analysis confirmed the stability and reliability of the findings. This meta-analysis of all available data did not support any appreciable association between the XRCC3 Thr241Met polymorphism and lung cancer risk in any populations.
Yun-Hua Xu; Lin-Ping Gu; Ying-Jia Sun; Bai-Jun Cheng; Shun Lu
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-9
Journal Detail:
Title:  Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine     Volume:  -     ISSN:  1423-0380     ISO Abbreviation:  Tumour Biol.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-9     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8409922     Medline TA:  Tumour Biol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Shanghai Lung Tumor Clinic Medical Center, Shanghai Chest Hospital, School of Medicine, Shanghai Jiao Tong University, No. 241 Huaihai West Road, Shanghai, 200030, China.
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