| No role for human herpes virus 8 in the etiology of infantile capillary hemangioma. | |
| | |
MedLine Citation:
|
PMID: 9237177 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Infantile capillary hemangiomas are vascular neoplasms that can appear quite infiltrative histologically and that are characterized by cords of cells with areas of marked cellularity. These lesions have been shown to contain a population of rapidly proliferative endothelial cells. Given the recent association between the presence of human herpes virus 8 (HHV8) and another proliferative vascular lesion, Kaposi's sarcoma, we used polymerase chain reaction technology to examine a series of 16 biopsy specimens from 15 infantile capillary hemangiomas for the presence of HHV8 DNA. We were unable to detect HHV8 DNA in any of the lesions studied. All of the cases were examined in parallel with a case of Kaposi's sarcoma that was known to be positive for HHV8 DNA and a series of negative controls. In all of our cases, amplification of beta-globin gene DNA demonstrated adequate preservation of DNA in the tissue studied. These findings suggest that not all endothelial cell proliferations can be attributed to HHV8 and that the etiology of some of these conditions remains unclear. |
| | |
Authors:
|
B R Smoller; P P Chang; O W Kamel |
Related Documents
:
|
230297 - Mode of integration of epstein-barr virus genome into host dna in burkitt lymphoma cells. 11801537 - Diagnostic and prognostic implications of circulating cell-free epstein-barr virus dna ... 8227437 - Epstein-barr virus in carcinoma of the vulva. 4521207 - Unique nuclear dna sequences in the involved tissues of hodgkin's and burkitt's lymphomas. 8346227 - A base-pairing interaction between u2 and u6 small nuclear rnas occurs in > 150s comple... 19388847 - Lead-, cadmium-, and arsenic-induced dna damage in rat germinal cells. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc Volume: 10 ISSN: 0893-3952 ISO Abbreviation: Mod. Pathol. Publication Date: 1997 Jul |
Date Detail:
|
Created Date: 1997-10-17 Completed Date: 1997-10-17 Revised Date: 2004-11-17 |
Medline Journal Info:
|
Nlm Unique ID: 8806605 Medline TA: Mod Pathol Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 675-8 Citation Subset: IM; X |
Affiliation:
|
Department of Pathology, Stanford University Medical Center, California 94305, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Capillaries
/
virology Child Child, Preschool DNA, Viral / analysis Female Hemangioendothelioma / chemistry, virology* Herpesvirus 8, Human / genetics, isolation & purification* Humans Infant Male Polymerase Chain Reaction Sarcoma, Kaposi / virology |
| Chemical | |
Reg. No./Substance:
|
0/DNA, Viral |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: HBME-1 immunostaining in thyroid fine-needle aspirations: a useful marker in the diagnosis of carcin...
Next Document: Molecular analysis of the IgH gene in 212 cases of Hodgkin's disease: correlation of IgH clonality w...