Document Detail

No positive effect of rhdnase on the pulmonary colonization in children with cystic fibrosis.
MedLine Citation:
PMID:  20499789     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Long-term clinical trials have shown that daily treatment with recombinant human deoxyribonuclease (rhDNAse) in patients with mild to moderate cystic fibrosis (CF) improves lung function and decreases the number of respiratory exacerbations. The aim of this study was to analyze the effect of rhDNAse on the bacterial colonization of the airways in children with CF. METHODS: This was a retrospective cohort study. From the database of the CF Center Utrecht, we selected two groups, an rhDNAse group (daily 2.5 mg rhDNAse) and a control group (no rhDNAse). Primary outcome parameter was the difference in change in bacterial colonization between the treatment and control group during 1.5-year. Secondary outcome parameters were changes in lung function (FEV1) and pulmonary exacerbations. RESULTS: Children treated with rhDNAse showed no significant changes in bacterial colonization during the treatment period, apart from an increase of P. aeruginosa positive cultures, both compared to baseline (53.1% versus 25%, p < 0.05) and control group (no change during study period, 37% versus 37%). The change in FEV1 after one year of treatment was +4.0% in the treatment group versus -0.3% in the control group (p = 0.22). There were no significant changes in number of pulmonary exacerbations. CONCLUSIONS: This study showed no significant beneficial decrease in bacterial airway colonization during 1.5-year of treatment with rhDNAse. The positive effects of rhDNAse on the lung function can therefore not be explained by a change in airway colonization.
H J C Bonestroo; M G Slieker; H G M Arets
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Monaldi archives for chest disease = Archivio Monaldi per le malattie del torace / Fondazione clinica del lavoro, IRCCS [and] Istituto di clinica tisiologica e malattie apparato respiratorio, Universit? di Napoli, Secondo ateneo     Volume:  73     ISSN:  1122-0643     ISO Abbreviation:  Monaldi Arch Chest Dis     Publication Date:  2010 Mar 
Date Detail:
Created Date:  2010-05-26     Completed Date:  2010-06-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9307314     Medline TA:  Monaldi Arch Chest Dis     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  12-7     Citation Subset:  IM    
Department of Pediatric Pulmonology, University Medical Center Utrecht, the Netherlands.
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MeSH Terms
Carrier State / prevention & control*
Case-Control Studies
Child, Preschool
Cystic Fibrosis / drug therapy*,  microbiology*
Deoxyribonucleases / therapeutic use*
Forced Expiratory Volume
Pseudomonas Infections / prevention & control
Pseudomonas aeruginosa / isolation & purification
Recombinant Proteins / therapeutic use*
Retrospective Studies
Reg. No./Substance:
0/Recombinant Proteins; EC 3.1.-/Deoxyribonucleases

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