Document Detail


No permanent reduction in bone mineral density during treatment of polymyalgia rheumatica and temporal arteritis using low dose corticosteroids.
MedLine Citation:
PMID:  10898068     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The objective of the study was to examine bone mineral density (BMD) in patients with polymyalgia rheumatica (PMR) or temporal arteritis (TA) currently or previously treated with prednisolone. BMD (using single or dual x-ray absorptiometry) was measured in radius, spine, and hip in 26 currently and 28 previously prednisolone treated patients with PMR (n = 38) or TA (n = 16). The prednisolone treated patients were compared to 30 newly diagnosed PMR (n = 26) or TA patients (n=4) examined prior to start of prednisolone, and 70 healthy controls. No statistically significant differences were found between the groups regarding age, height, weight, and gender. For current users of prednisolone, the mean daily dose was 6.5 mg, the mean cumulative dose 7.7 grams, and for previous users 5.6 mg and 6.6 grams, respectively. No statistically significant differences in BMD at the different measurement sites were found between prednisolone treated patients and the two control groups. Similarly, no significant differences in BMD were found between current and previous users of prednisolone and between the prednisolone treated PMR and TA patients. In conclusion, BMD is not substantially reduced in PMR and TA patients currently or previously treated with mean low dose prednisolone. However, a tendency to a lower BMD was found in PMR/TA patients currently treated with prednisolone and in the prednisolone treated TA patients.
Authors:
G Haugeberg; G Myklebust; H Dovland; B Mikkelsen; J T Gran
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Scandinavian journal of rheumatology     Volume:  29     ISSN:  0300-9742     ISO Abbreviation:  Scand. J. Rheumatol.     Publication Date:  2000  
Date Detail:
Created Date:  2000-07-28     Completed Date:  2000-07-28     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0321213     Medline TA:  Scand J Rheumatol     Country:  NORWAY    
Other Details:
Languages:  eng     Pagination:  163-9     Citation Subset:  IM    
Affiliation:
Department of Rheumatology, Vest-Agder Central Hospital, Kristiansand, Norway. ghaugebe@online.no
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MeSH Terms
Descriptor/Qualifier:
Absorptiometry, Photon
Aged
Bone Density / drug effects*
Bone and Bones / metabolism
Cross-Sectional Studies
Female
Giant Cell Arteritis / drug therapy*,  metabolism
Glucocorticoids / administration & dosage*
Humans
Male
Polymyalgia Rheumatica / drug therapy*,  metabolism
Prednisolone / administration & dosage*
Chemical
Reg. No./Substance:
0/Glucocorticoids; 50-24-8/Prednisolone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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