Document Detail


No oxygen delivery limitation in hepatic encephalopathy.
MedLine Citation:
PMID:  20182779     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Hepatic encephalopathy is a condition of reduced brain functioning in which both blood flow and brain energy metabolism declined. It is not known whether blood flow or metabolism is the primary limiting factor of brain function in this condition. We used calculations of mitochondrial oxygen tension to choose between cause and effect in three groups of volunteers, including healthy control subjects (HC), patients with cirrhosis of the liver without hepatic encephalopathy (CL), and patients with cirrhosis with acute hepatic encephalopathy. Compared to HC subjects, blood flow and energy metabolism had declined in all gray matter regions of the brain in patients with HE but not significantly in patients with CL. Analysis of flow-metabolism coupling indicated that blood flow declined in HE as a consequence of reduced brain energy metabolism implied by the calculation of increased mitochondrial oxygen tensions that patients with HE were unable to utilize. We ascribe the inability to use the delivered oxygen of patients with HE to a specific inhibition associated with oxidative metabolism in mitochondria.
Authors:
Albert Gjedde; Susanne Keiding; Hendrik Vilstrup; Peter Iversen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-02-25
Journal Detail:
Title:  Metabolic brain disease     Volume:  25     ISSN:  1573-7365     ISO Abbreviation:  Metab Brain Dis     Publication Date:  2010 Mar 
Date Detail:
Created Date:  2010-04-07     Completed Date:  2010-07-01     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8610370     Medline TA:  Metab Brain Dis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  57-63     Citation Subset:  IM    
Affiliation:
Pathophysiology and Experimental Tomography Center, Aarhus Hospital, Aarhus University Hospitals, Aarhus, Denmark. gjedde@sund.ku.dk
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MeSH Terms
Descriptor/Qualifier:
Aged
Basal Metabolism / physiology
Brain / blood supply,  metabolism*,  physiopathology
Cerebrovascular Circulation / physiology
Energy Metabolism / physiology*
Female
Fibrosis / metabolism,  physiopathology
Hepatic Encephalopathy / diagnosis,  metabolism*,  physiopathology
Humans
Male
Middle Aged
Mitochondria / metabolism
Oxygen / analysis,  metabolism
Oxygen Consumption / physiology*
Chemical
Reg. No./Substance:
7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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