Document Detail


No link between rosacea and Propionibacterium acnes.
MedLine Citation:
PMID:  23009116     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Rosacea is a common skin disease in adults affecting mainly the facial skin. Although inflammation appears to play a pathogenic role in rosacea, initiating factors are largely unknown. Microbial involvement in the development of rosacea has been suggested previously. We aimed to visualize Propionibacterium acnes in the skin compartments of rosacea patients. Facial skin biopsies from 82 rosacea patients and 25 controls were stained with a P. acnes-specific monoclonal antibody (QUBPa3). Seven of 82 patients (8.5%) tested positive for P. acnes which was present either as a biofilm (57% of positive) or a microcolony (43%) in colonized patients. Our results suggest that P. acnes does not play a major role in the pathogenesis of rosacea.
Authors:
Anika C Jahns; Bertil Lundskog; Ida Dahlberg; Natalia Curiche Tamayo; Andrew McDowell; Sheila Patrick; Oleg A Alexeyev
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Publication Detail:
Type:  Journal Article     Date:  2012-05-18
Journal Detail:
Title:  APMIS : acta pathologica, microbiologica, et immunologica Scandinavica     Volume:  120     ISSN:  1600-0463     ISO Abbreviation:  APMIS     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-09-26     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8803400     Medline TA:  APMIS     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  922-5     Citation Subset:  IM    
Copyright Information:
© 2012 The Authors APMIS © 2012 APMIS.
Affiliation:
Department of Medical Biosciences/Pathology, Umeå University, Umeå, Sweden.
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