Document Detail

No increased risk of adverse pregnancy outcomes for women with myasthenia gravis: a nationwide population-based study.
MedLine Citation:
PMID:  19486132     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: This study aims to examine the risk of adverse pregnancy outcomes [low birthweight (LBW), preterm birth, cesarean sections (CS) and babies born small for gestational age (SGA)] in pregnant women with myasthenia gravis (MG), using a 3-year population-based database, taking characteristics of infant and mother into consideration. METHODS: This study used two nationwide population-based datasets: the Taiwan National Health Insurance Research Dataset and the Taiwan birth certificate registry. We identified 163 pregnant women with MG during 2001-2003 as the study cohort and 815 randomly selected pregnant women as a comparison cohort. Conditional logistic regression analyses were performed. RESULTS: The results showed that, although these patterns did not reach a statistically significant level, mothers with MG had higher percentages of LBW (6.8%, vs. 5.6%), SGA (17.8%, vs. 14.1%) and cesarean deliveries (44.8%, vs. 37.4%), except for preterm births (8.1%, vs. 8.1%). After adjusting for highest maternal education level, marital status, family monthly income and infant gender and parity, the odds ratios (OR) of LBW, preterm birth, SGA infants, and cesarean delivery for mothers with MG were 1.19 (95% CI = 0.60-2.38), 1.00 (95% CI = 0.54-1.87), 1.30 (95% CI = 0.83-2.04), and 1.33 (95% CI = 0.94-1.88), respectively, as compared to unaffected mothers. CONCLUSIONS: We conclude that there were no statistically significant differences in the risk of having preterm, LBW, SGA infants and cesarean deliveries between women with and without MG.
J-C Wen; T-C Liu; Y-H Chen; S-F Chen; H-C Lin; W-C Tsai
Publication Detail:
Type:  Journal Article     Date:  2009-05-22
Journal Detail:
Title:  European journal of neurology : the official journal of the European Federation of Neurological Societies     Volume:  16     ISSN:  1468-1331     ISO Abbreviation:  Eur. J. Neurol.     Publication Date:  2009 Aug 
Date Detail:
Created Date:  2009-07-27     Completed Date:  2009-10-19     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9506311     Medline TA:  Eur J Neurol     Country:  England    
Other Details:
Languages:  eng     Pagination:  889-94     Citation Subset:  IM    
Department of Internal Medicine, PoJen General Hospital, Taipei, Taiwan.
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MeSH Terms
Cesarean Section
Cohort Studies
Databases, Factual
Educational Status
Infant, Low Birth Weight
Infant, Newborn
Infant, Small for Gestational Age
Logistic Models
Myasthenia Gravis / epidemiology*
Odds Ratio
Pregnancy Complications / epidemiology*
Pregnancy Outcome*
Premature Birth
Socioeconomic Factors
Young Adult

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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