Document Detail

No increase in long-term risk for nicotine use disorders after treatment with methylphenidate in children with attention-deficit/hyperactivity disorder (ADHD): evidence from a non-randomised retrospective study.
MedLine Citation:
PMID:  18253808     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To evaluate long-term effects of methylphenidate (MPH) treatment in ADHD children on the development of nicotine use disorders (SUD-N). METHODS: Multisite retrospective non-randomised longitudinal study with 215 ADHD children (diagnosis at 9.2 years of age; reassessment for SUD-N at 21.9 years of age) strictly parallel allocated to MPH treated (n = 106) and drug naive (n = 109) children. RESULTS: There was no difference between the groups with respect to frequency (84% MPH; 89% non-MPH; chi(2) = 1.6; p = 0.21) and age of onset for first cigarette smoking (log rank 1.68; p = 0.19). Continuous smoking was reached by 51% (MPH) and 61% (non-MPH) of the patients. Survival analyses revealed a small and nominally significant delay in age of onset for continuous smoking in the MPH-group (log rank = 3.85; p = 0.049). Nicotine dependency was reached by 20% (MPH) and 27% (non-MPH). Age of onset does not differ between groups (log rank = 2.24; p = 0.13). DISCUSSION: Limited evidence due to the non-randomised nature of the study is given that MPH does not induce SUD-N. The data suggests there may be a beneficial effect of MPH on delay of onset for continuous nicotine consumption in ADHD patients.
M Huss; F Poustka; G Lehmkuhl; U Lehmkuhl
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-02-08
Journal Detail:
Title:  Journal of neural transmission (Vienna, Austria : 1996)     Volume:  115     ISSN:  0300-9564     ISO Abbreviation:  J Neural Transm     Publication Date:  2008  
Date Detail:
Created Date:  2008-02-18     Completed Date:  2008-05-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9702341     Medline TA:  J Neural Transm     Country:  Austria    
Other Details:
Languages:  eng     Pagination:  335-9     Citation Subset:  IM    
Head of Department for Child and Adolescent Psychiatry, Johannes Gutenberg-University, Mainz, Germany.
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MeSH Terms
Age Factors
Attention Deficit Disorder with Hyperactivity / drug therapy
Central Nervous System Stimulants / adverse effects*
Methylphenidate / adverse effects*
Retrospective Studies
Survival Analysis
Tobacco Use Disorder / etiology*
Reg. No./Substance:
0/Central Nervous System Stimulants; 113-45-1/Methylphenidate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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