Document Detail

No increase of biliary permeability in ethinylestradiol-treated rats.
MedLine Citation:
PMID:  6884706     Owner:  NLM     Status:  MEDLINE    
Ethinylestradiol, administered to male Wistar rats for 5 days (5 mg/kg X day), decreased bile flow in anesthetized animals and in isolated perfused livers. The bile salt secretion rate was diminished. The bile-to-perfusate ratios of [14C]sucrose and [14C]inulin increased significantly, but this could be attributed to the decline of bile flow as indicated by almost identical clearance rates. Theorectical analysis according to Forker and Wheeler yielded diffusion permeability coefficients (K) for sucrose and inulin of 0.243 and 0.037 in controls and 0.273 and 0.038 in ethinylestradiol-treated rats. In contrast, 9 h of alpha-naphthylisothiocyanate treatment (250 mg/kg) caused cholestasis with heavily decreased bile salt secretion rates. Here, K-values calculated for sucrose and inulin were 0.807 and 0.175. These findings suggest that altered permeability of the paracellular pathway is the cause for alpha-naphthylisothiocyanate-induced cholestasis, but not the primary event in ethinylestradiol-induced cholestasis.
H Jaeschke; H Krell; E Pfaff
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Gastroenterology     Volume:  85     ISSN:  0016-5085     ISO Abbreviation:  Gastroenterology     Publication Date:  1983 Oct 
Date Detail:
Created Date:  1983-10-21     Completed Date:  1983-10-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0374630     Medline TA:  Gastroenterology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  808-14     Citation Subset:  AIM; IM    
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MeSH Terms
1-Naphthylisothiocyanate / pharmacology
Bile / metabolism*,  secretion
Bile Acids and Salts / secretion
Biliary Tract / metabolism*
Cholestasis / chemically induced
Ethinyl Estradiol / adverse effects,  pharmacology*
Inulin / metabolism
Rats, Inbred Strains
Sucrose / metabolism
Reg. No./Substance:
0/Bile Acids and Salts; 551-06-4/1-Naphthylisothiocyanate; 57-50-1/Sucrose; 57-63-6/Ethinyl Estradiol; 9005-80-5/Inulin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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