Document Detail

No improvement in cardiovascular risk factors in overweight and obese subjects after supplementation with vitamin D3 for 1 year.
MedLine Citation:
PMID:  20141565     Owner:  NLM     Status:  MEDLINE    
BACKGROUND AND AIM: Cross-sectional studies indicate vitamin D to be of importance for glucose tolerance, blood pressure and serum lipids, but whether supplementation with vitamin D would improve cardio-vascular risk factors is not known. DESIGN AND SETTING: The study was a 1 year, double blind placebo-controlled intervention trial performed at the University Hospital of North Norway from November 2005 to October 2007. Subjects. A total of 438 overweight or obese subjects, 21-70 years old, were included and 330 completed the study. INTERVENTIONS: The subjects were randomized to vitamin D (cholecalciferol, vitamin D(3)) 40 000 IU per week (DD group), vitamin D 20 000 IU per week (DP group), or placebo (PP group). All subjects were given 500 mg calcium daily. MAIN OUTCOME MEASURES: Fasting serum lipids and blood pressure were measured and an oral glucose tolerance test performed at start and end of the study. RESULTS: At baseline the mean serum 25(OH)D levels were 58 nmol L(-1) (all subjects) and increased to 140 and 101 nmol L(-1) in the DD and DP groups, respectively. No significant differences were found between the three groups regarding change in measures of glucose metabolism or serum lipids. In the DP group, there was a slight but significant increase in systolic blood pressure compared with the placebo group. CONCLUSIONS: Our results do not support a positive effect of vitamin D on glucose tolerance, blood pressure or serum lipids. Further studies in subjects with low serum 25(OH)D levels combined with impaired glucose tolerance, hypertension or dyslipidaemia are needed.
R Jorde; M Sneve; P Torjesen; Y Figenschau
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial     Date:  2009-10-19
Journal Detail:
Title:  Journal of internal medicine     Volume:  267     ISSN:  1365-2796     ISO Abbreviation:  J. Intern. Med.     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-05-03     Completed Date:  2010-06-14     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8904841     Medline TA:  J Intern Med     Country:  England    
Other Details:
Languages:  eng     Pagination:  462-72     Citation Subset:  IM    
Institute of Clinical Medicine, University of Troms?, Troms?, Norway.
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MeSH Terms
Blood Glucose / metabolism
Blood Pressure
Cardiovascular Diseases / etiology*
Cholecalciferol / therapeutic use*
Cross-Sectional Studies
Double-Blind Method
Fasting / blood
Lipids / blood
Middle Aged
Obesity / blood,  complications,  drug therapy*
Overweight / blood,  complications,  drug therapy
Risk Factors
Vitamins / therapeutic use*
Young Adult
Reg. No./Substance:
0/Blood Glucose; 0/Lipids; 0/Vitamins; 67-97-0/Cholecalciferol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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