Document Detail

No fine motor deficits in patients with untreated non-phenylketonuria hyperphenylalaninaemia.
MedLine Citation:
PMID:  8695989     Owner:  NLM     Status:  MEDLINE    
Twenty-four untreated adolescent and adult patients with non-phenylketonuria (PKU) hyperphenylalaninaemia (HPA) (serum phenylalanine levels < 600 mumol l-1) and 24 healthy controls matched for age, sex and IQ were investigated for their neurological outcome, especially for fine motor abilities by the Motor Performance Task. No pathological findings could be revealed by clinical neurological examination. Patients with HPA and healthy controls did not significantly differ in their fine motor performances. These performances were not significantly influenced by serum phenylalanine concentrations. Our results indicate that untreated patients with non-PKU HPA are not at clinically significant risk for developing fine motor deficits and severe neurological impairment. From this point of view a dietary treatment is not necessary in patients with HPA, as recommended most recently.
J Weglage; K Ullrich; M Pietsch; B Fünders; R Zass; H G Koch
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta paediatrica (Oslo, Norway : 1992)     Volume:  85     ISSN:  0803-5253     ISO Abbreviation:  Acta Paediatr.     Publication Date:  1996 Mar 
Date Detail:
Created Date:  1996-09-03     Completed Date:  1996-09-03     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9205968     Medline TA:  Acta Paediatr     Country:  NORWAY    
Other Details:
Languages:  eng     Pagination:  320-3     Citation Subset:  IM    
Department of Paediatrics, University of Münster, Germany.
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MeSH Terms
Motor Skills*
Phenylalanine / blood*
Reg. No./Substance:

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