| No extreme genetic risk for type 1 diabetes among DR3/4-DQ8 siblings sharing both extended HLA haplotypes with their diabetic proband. | |
| | |
MedLine Citation:
|
PMID: 21388358 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
An extreme genetic risk for type 1 diabetes (T1D) was reported for DR3/4-DQ8 siblings sharing both extended human leukocyte antigen (HLA) haplotypes identical-by-descent (IBD) with their diabetic proband. We attempted to replicate this finding in our prospective Dutch T1D cohort and in families from the Type 1 Diabetes Genetics Consortium (T1DGC). Only 2 of the 14 Dutch siblings, sharing both DR3-DQ2/DR4-DQ8 haplotypes IBD with their diabetic proband, developed T1D in a 12-year follow-up period. No differential sharing of HLA haplotypes or significant transmission distortion in parents homozygous for HLA risk alleles was found in T1DGC material. Therefore, we could not confirm the reported extreme risk for T1D, suggesting that the risk conferred by other HLA complex loci is moderate. |
| | |
Authors:
|
P Eerligh; B P C Koeleman; B A Lie; B O Roep; E Thorsby |
Related Documents
:
|
10566598 - Influence of tnf microsatellite polymorphisms (tnfa) on age-at-onset of insulin-depende... 3969598 - Hla antigens and non-insulin-dependent diabetes mellitus in young south african indians. 720778 - Hla-typing in juvenile diabetics with and without positive family history and in famili... 2888188 - Matching of host genotype and serotypes of coxsackie b virus in the development of juve... 3223188 - Personality examinations in individuals with insulin-dependent diabetes mellitus. 21334758 - Investigation of early change of endothelial function and related factors in individual... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Tissue antigens Volume: 77 ISSN: 1399-0039 ISO Abbreviation: Tissue Antigens Publication Date: 2011 Apr |
Date Detail:
|
Created Date: 2011-03-10 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0331072 Medline TA: Tissue Antigens Country: Denmark |
Other Details:
|
Languages: eng Pagination: 338-40 Citation Subset: IM |
Copyright Information:
|
© 2011 John Wiley & Sons A/S. |
Affiliation:
|
Department of Immunohaematology & Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands Department of Medical Genetics, University Medical Center, Utrecht, The Netherlands Institute of Immunology, Oslo University Hospital, Rikshospitalet, Oslo, Norway. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Caspase recruitment domain 15 gene haplotypes in sarcoidosis.
Next Document: Identification of a novel HLA-B*35:42:02 allele in a Chinese bone marrow donor.