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No evidence for a putative involvement of platelet-activating factor in systemic lupus erythematosus without active nephritis.
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MedLine Citation:
PMID:  12775360     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Platelet-activating factor (PAF) seems to be implicated in systemic lupus erythematosus (SLE) patients with associated renal diseases. AIMS: In this study, we ensured the role of PAF in SLE patients without renal complications. METHODS: Blood PAF and acetylhydrolase activity, plasma soluble phospholipase A(2), and the presence of antibodies against PAF were investigated in 17 SLE patients without active nephritis and in 17 healthy controls. RESULTS: Blood PAF levels were not different (p=0.45) between SLE patients (6.7+/-2.8 pg/ml) and healthy subjects (9.6+/-3.1 pg/ml). Plasma acetylhydrolase activity (the PAF-degrading enzyme) was significantly (p=0.03) elevated in SLE patients (57.8+/-6.4 nmol/min/ml) as compared with controls (37.9+/-2.6 nmol/min/ml). Plasma soluble phospholipase A(2) (the key enzyme for PAF formation) was not different (p=0.6) between SLE patients (59.1+/-5.1 U/ml) and controls (54.7+/-2.4 U/ml). Antibodies against PAF were detected only in 3/17 SLE patients. Flow cytometry analysis did not highlight PAF receptors on circulating leukocytes of SLE patients. CONCLUSION: This clinical study highlights no evidence for a putative important role of PAF in SLE patients without active nephritis.
Authors:
Yves Denizot; Eric Liozon; Laurence Guglielmi; Kim Ly; Pascale Soria; Véronique Loustaud; Elisabeth Vidal; Marie Odile Jauberteau
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Mediators of inflammation     Volume:  12     ISSN:  0962-9351     ISO Abbreviation:  Mediators Inflamm.     Publication Date:  2003 Apr 
Date Detail:
Created Date:  2003-05-30     Completed Date:  2004-02-23     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  9209001     Medline TA:  Mediators Inflamm     Country:  England    
Other Details:
Languages:  eng     Pagination:  101-5     Citation Subset:  IM    
Affiliation:
UMR CNRS 6101, Laboratoire d'Immunologie, Faculté de Médecine, 2 rue Dr Marcland, 87025 Limoges, France. yves.denizot@unilim.fr
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MeSH Terms
Descriptor/Qualifier:
1-Alkyl-2-acetylglycerophosphocholine Esterase / blood
Acute Disease
Adult
Aged
Aged, 80 and over
Autoantibodies / blood
Female
Humans
Lupus Nephritis / blood,  immunology*
Male
Middle Aged
Phospholipases A / blood
Platelet Activating Factor / immunology*,  metabolism
Chemical
Reg. No./Substance:
0/Autoantibodies; 0/Platelet Activating Factor; EC 3.1.1.-/Phospholipases A; EC 3.1.1.47/1-Alkyl-2-acetylglycerophosphocholine Esterase
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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Journal Information
Journal ID (nlm-ta): Mediators Inflamm
ISSN: 0962-9351
Article Information
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Print publication date: Month: 4 Year: 2003
Volume: 12 Issue: 2
First Page: 101 Last Page: 105
ID: 1781601
PubMed Id: 12775360
DOI: 10.1080/0962935031000097718
Publisher Item Identifier: MA13BDHG2TKXWE8D

No evidence for a putative involvement of platelet-activating factor in systemic lupus erythematosus without active nephritis.
Yves Denizot Email: yves.denizot@unilim.fr
Eric Liozon
Laurence Guglielmi
Kim Ly
Pascale Soria
V?ronique Loustaud
Elisabeth Vidal
Marie Odile Jauberteau
UMR CNRS 6101, Laboratoire d'Immunologie, Facult? de M?decine, 2 rue Dr Marcland, 87025 Limoges, France.


Article Categories:
  • Research Article


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