Document Detail


No evidence for the presence of apolipoprotein epsilon4, interleukin-lalpha allele 2 and interleukin-1beta allele 2 cause an increase in programmed cell death following traumatic brain injury in humans.
MedLine Citation:
PMID:  17140155     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Brain injury after trauma is an important cause of mortality and morbidity in society. There is evidence in both man and laboratory animals that in addition to necrosis, cell loss may occur as a result of programmed cell death (PCD). The cellular and molecular responses after head injury are partly influenced by genetic polymorphisms of apolipoprotein E and the pro-inflammatory cytokine IL-I. AIM: The principal aim of this study was to determine whether the presence of the ApoE epsilon4, IL- 1 alpha2 or IL- 1beta2 allele types influenced the amounts of PCD after head injury compared with controls. METHODS: Paraffin sections from the hippocampus of 38 patients (32 M : 6 F, aged 15 - 75, mean 38 years, survival 7- 576 hours; mean 36 hours) who died after a head injury were stained by Tunel histochemistry and quantified, and genotyping was undertaken by PCR "blind" to clinical detail. RESULTS: There were more Tunel+ cells (neurons and glia) after head injury than in controls with statistically increased numbers in all sectors of the hippocampus including the dentate fascia. However, there was no correlation between ApoEepsilon4, IL- 1 alpha allele 2 and IL- 1beta allele 2 and the amount of Tunel positivity. CONCLUSION: Given that both the ApoE and IL-1 influence outcome after various forms of acute brain injury, further work will be required to determine the mechanism underlying this relationship.
Authors:
V E Johnson; L Murray; R Raghupathi; J Stewart; J A R Nicoll; M A MacKinnon; T K McIntosh; D I Graham
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Clinical neuropathology     Volume:  25     ISSN:  0722-5091     ISO Abbreviation:  Clin. Neuropathol.     Publication Date:    2006 Nov-Dec
Date Detail:
Created Date:  2006-12-04     Completed Date:  2007-01-05     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  8214420     Medline TA:  Clin Neuropathol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  255-64     Citation Subset:  IM    
Affiliation:
Academic Unit of Neuropathology, University of Glasgow, Glasgow, Scotland, UK.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Apolipoprotein E4 / genetics*
Apoptosis / genetics*
Biological Markers / metabolism
Brain Injuries / genetics*,  immunology,  metabolism
Cell Count
DNA Mutational Analysis
Female
Gene Frequency
Genetic Predisposition to Disease / genetics*
Genetic Testing
Genotype
Hippocampus / metabolism,  pathology,  physiopathology
Humans
In Situ Nick-End Labeling
Interleukin-1 / genetics*
Interleukin-1alpha / genetics
Interleukin-1beta / genetics
Male
Middle Aged
Nerve Degeneration / genetics*,  immunology,  metabolism
Polymorphism, Genetic / genetics
Grant Support
ID/Acronym/Agency:
5-P05-NS008803-30/NS/NINDS NIH HHS
Chemical
Reg. No./Substance:
0/Apolipoprotein E4; 0/Biological Markers; 0/Interleukin-1; 0/Interleukin-1alpha; 0/Interleukin-1beta

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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