Document Detail


No evidence of microbleeds in ALS patients at 7 Tesla MRI.
MedLine Citation:
PMID:  20812888     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
There have been several reports about disruption of the blood-spinal cord barrier (BSCB) and blood-brain barrier (BBB) in SOD1 mutant mice. Pathologically, microbleeds and hemosiderine deposits were found. We investigated patients with ALS for the occurrence of cerebral microbleeds with 7 Tesla MRI. Twelve patients with ALS and 12 age- and sex-matched healthy controls were studied. We performed T2*-weighed imaging which enables whole-brain in vivo detection of cerebral microbleeds and hemosiderin deposits in humans. No microbleeds were found in patients with ALS.
Authors:
Esther Verstraete; Geert-Jan Biessels; Martijn P van Den Heuvel; Fredy Visser; Peter R Luijten; Leonard H van Den Berg
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-09-03
Journal Detail:
Title:  Amyotrophic lateral sclerosis : official publication of the World Federation of Neurology Research Group on Motor Neuron Diseases     Volume:  11     ISSN:  1471-180X     ISO Abbreviation:  Amyotroph Lateral Scler     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-11-16     Completed Date:  2011-02-28     Revised Date:  2011-06-22    
Medline Journal Info:
Nlm Unique ID:  101283386     Medline TA:  Amyotroph Lateral Scler     Country:  England    
Other Details:
Languages:  eng     Pagination:  555-7     Citation Subset:  IM    
Affiliation:
Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Centre Utrecht, Utrecht. E.Verstraete@umcutrecht.nl
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MeSH Terms
Descriptor/Qualifier:
Adult
Amyotrophic Lateral Sclerosis / pathology*,  physiopathology
Animals
Blood-Brain Barrier / pathology
Brain / pathology*
Cerebrovascular Circulation*
Hemosiderin
Humans
Magnetic Resonance Imaging / methods*
Mice
Microcirculation*
Middle Aged
Chemical
Reg. No./Substance:
9011-92-1/Hemosiderin
Comments/Corrections
Comment In:
Amyotroph Lateral Scler. 2011 May;12(3):231-2; author reply 233-4   [PMID:  21413850 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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