| No evidence of microbleeds in ALS patients at 7 Tesla MRI. | |
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MedLine Citation:
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PMID: 20812888 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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There have been several reports about disruption of the blood-spinal cord barrier (BSCB) and blood-brain barrier (BBB) in SOD1 mutant mice. Pathologically, microbleeds and hemosiderine deposits were found. We investigated patients with ALS for the occurrence of cerebral microbleeds with 7 Tesla MRI. Twelve patients with ALS and 12 age- and sex-matched healthy controls were studied. We performed T2*-weighed imaging which enables whole-brain in vivo detection of cerebral microbleeds and hemosiderin deposits in humans. No microbleeds were found in patients with ALS. |
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Authors:
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Esther Verstraete; Geert-Jan Biessels; Martijn P van Den Heuvel; Fredy Visser; Peter R Luijten; Leonard H van Den Berg |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-09-03 |
Journal Detail:
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Title: Amyotrophic lateral sclerosis : official publication of the World Federation of Neurology Research Group on Motor Neuron Diseases Volume: 11 ISSN: 1471-180X ISO Abbreviation: Amyotroph Lateral Scler Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-11-16 Completed Date: 2011-02-28 Revised Date: 2011-06-22 |
Medline Journal Info:
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Nlm Unique ID: 101283386 Medline TA: Amyotroph Lateral Scler Country: England |
Other Details:
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Languages: eng Pagination: 555-7 Citation Subset: IM |
Affiliation:
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Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Centre Utrecht, Utrecht. E.Verstraete@umcutrecht.nl |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Amyotrophic Lateral Sclerosis / pathology*, physiopathology Animals Blood-Brain Barrier / pathology Brain / pathology* Cerebrovascular Circulation* Hemosiderin Humans Magnetic Resonance Imaging / methods* Mice Microcirculation* Middle Aged |
| Chemical | |
Reg. No./Substance:
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9011-92-1/Hemosiderin |
| Comments/Corrections | |
Comment In:
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Amyotroph Lateral Scler. 2011 May;12(3):231-2; author reply 233-4
[PMID:
21413850
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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