| No evidence for links between autism, MMR and measles virus. | |
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MedLine Citation:
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PMID: 15259839 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: We examined whether, in the UK, there is an increased risk of autism (AD) following exposures, in early life, to: (1) wild measles; (2) live attenuated measles, alone or in combination as MMR; and (3) the alteration of the mumps strain within MMR. METHOD: We conducted time trend analyses of 2407 AD subjects born between 1959-93; and for comparison, 4640 Down's syndrome (DS) subjects born between 1966-93. Between 1968-86, we correlated variations in AD and DS births with wild measles incidence. Between 1959-93, we tested for abrupt changes in the long-term AD birth trend for the effects of introducing: (1) monovalent measles vaccines in 1968; (2) MMR immunization in 1988; and (3) the 'overnight switch' from mixed use of Urabe MMR to exclusive use of Jeryl-Lynn MMR in 1992. Incidence rate ratios (IRRs) were used as measures of association. RESULTS: We found no significant association between AD births and exposure (prenatal and postnatal up to 18 months age) to population rates of measles infections, and no 'step-up' increase in AD births associated with the introduction of monovalent measles and MMR vaccines, and changing mumps strain. An unexpected reduction in AD births of 21% (95% CI 6.9-33.3%; P=0.005) among the post-1987 birth cohorts was detected. CONCLUSION: No increased risk of AD following exposures to wild measles and vaccinations with monovalent measles, and Urabe or Jeryl-Lynn variants of MMR was detected. The precise meaning of the detected AD births reduction is unclear. Our study cannot exclude rare complications of MMR, given its correlational design. |
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Authors:
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W Chen; S Landau; P Sham; E Fombonne |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Psychological medicine Volume: 34 ISSN: 0033-2917 ISO Abbreviation: Psychol Med Publication Date: 2004 Apr |
Date Detail:
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Created Date: 2004-07-19 Completed Date: 2004-08-03 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 1254142 Medline TA: Psychol Med Country: England |
Other Details:
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Languages: eng Pagination: 543-53 Citation Subset: IM |
Affiliation:
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Institute of Psychiatry, King's College and Department of Child and Adolescent Psychiatry, Guy's, King's and St Thomas's School of Medicine, University of London. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Autistic Disorder
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epidemiology*,
virology* Disease Notification / statistics & numerical data Female Great Britain / epidemiology Humans Immunization Programs Male Measles / complications*, epidemiology* Measles Vaccine / administration & dosage, adverse effects* Measles-Mumps-Rubella Vaccine / administration & dosage, adverse effects* |
| Chemical | |
Reg. No./Substance:
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0/Measles Vaccine; 0/Measles-Mumps-Rubella Vaccine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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