Document Detail

No evidence for linkage between chromosome 5 markers and schizophrenia.
MedLine Citation:
PMID:  2335365     Owner:  NLM     Status:  MEDLINE    
Linkage between chromosome 5 markers and schizophrenia has been proposed for a small number of Icelandic and English families. Three subsequent reports have failed to replicate this report. To increase the number of tested kindreds, we collected seven North American families with schizophrenia and genotyped them at 4 loci that span the region 5p13-5q11-14, including the two markers used in the single positive linkage report. The data were analyzed with models of affection status similar to those utilized in the positive report. We observed no evidence of linkage between these markers and psychiatric disorders, regardless of the definition of affection status. Additionally, we can exclude most of the region for linkage with schizophrenia in these families. This and other negative reports of linkage between schizophrenia and chromosome 5 markers suggest that genetic defects in this region are rarely, if ever, etiologically related to schizophrenia.
H N Aschauer; G Aschauer-Treiber; K E Isenberg; R D Todd; M A Knesevich; D L Garver; T Reich; C R Cloninger
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Human heredity     Volume:  40     ISSN:  0001-5652     ISO Abbreviation:  Hum. Hered.     Publication Date:  1990  
Date Detail:
Created Date:  1990-06-13     Completed Date:  1990-06-13     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0200525     Medline TA:  Hum Hered     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  109-15     Citation Subset:  IM    
Department of Psychiatry, University of Vienna, Austria.
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MeSH Terms
Chromosomes, Human, Pair 5*
Genetic Markers
Linkage (Genetics)*
Lod Score
Models, Genetic
Recombination, Genetic
Schizophrenia / genetics*
Grant Support
Reg. No./Substance:
0/Genetic Markers

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