Document Detail

No evidence of hypersensitivity to dental restorative metals in oral lichen planus.
MedLine Citation:
PMID:  3306889     Owner:  NLM     Status:  MEDLINE    
Twelve patients with oral lichen planus (OLP) suspected of dental restorative metal allergy were examined. All patients were patch tested with several metals including six different mercury compounds. One (8%) patient showed a positive patch test to two mercury compounds whereas no mercury allergy was found in a reference group of 17 patients suspected of dental restorative material allergy but without OLP lesions. The mercury allergic OLP patient was further tested on palatal mucosa but no reactions developed. Moreover, the energy dispersive X-ray microanalysis failed to show any contaminating metals in his OLP lesion. Mucosal biopsies were taken in close contact with amalgam fillings from nine OLP patients but these disclosed no evidence of lichenoid or dysplastic alterations. In OLP lesions, the immunofluorescence findings showed fibrinogen deposition, altered basement membrane and elastic fiber staining and intense Ulex europeaus I lectin fluorescence through all epithelial cell layers. Therefore, the present patch tests did not reveal increased frequency of mercury or other metal allergy in OLP patients and the mucosal biopsies failed to show any histologic or immunofluorescence alterations deviating from idiopathic OLP lesions.
J Hietanen; K Pihlman; L Förström; E Linder; T Reunala
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Scandinavian journal of dental research     Volume:  95     ISSN:  0029-845X     ISO Abbreviation:  Scand J Dent Res     Publication Date:  1987 Aug 
Date Detail:
Created Date:  1987-10-07     Completed Date:  1987-10-07     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0270023     Medline TA:  Scand J Dent Res     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  320-7     Citation Subset:  D; IM    
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MeSH Terms
Dental Alloys / adverse effects*,  analysis
Dental Amalgam / adverse effects,  analysis
Electron Probe Microanalysis
Fluorescent Antibody Technique
Hypersensitivity / diagnosis*,  etiology
Lichen Planus* / pathology
Middle Aged
Mouth Diseases* / pathology
Patch Tests
Reg. No./Substance:
0/Dental Alloys; 8049-85-2/Dental Amalgam

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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