Document Detail

No evidence for a higher resting metabolic rate in noninstitutionalized Alzheimer's disease patients.
MedLine Citation:
PMID:  8856004     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: It has previously been suggested that Alzheimer's disease patients have higher resting energy requirements than healthy individuals, which may contribute to their unexplained weight loss. We examined whether resting metabolic rate, the largest component of daily energy expenditure, is elevated in Alzheimer's patients compared with healthy older controls. DESIGN: Cross-sectional. SETTING: General Clinical Research Center and Baltimore VA Medical Center. PATIENTS: Twenty-five noninstitutionalized demented patients (74 +/- 8 years; mean +/- SD) with a wide range of Mini-Mental Examination scores (1 to 20) and 73 healthy older individuals (69 +/- 7 years). MEASUREMENTS: Resting metabolic rate was measured by indirect calorimetry, fat-free mass and fat mass by dual energy X-ray absorptiometry, and daily energy intake by food diaries. RESULTS: No differences in fat-free mass and fat mass were noted between Alzheimer's disease patients and healthy older controls. Resting metabolic rate was similar in Alzheimer's disease patients (5446 +/- 962 kJ/day) and healthy older individuals (5647 +/- 887 kJ/day). These results persisted when resting metabolic rate was statistically adjusted for differences in body composition and age. CONCLUSION: These results provide no evidence for an elevation in resting energy requirements in noninstitutionalized demented patients.
K E Donaldson; W H Carpenter; M J Toth; M I Goran; P Newhouse; E T Poehlman
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of the American Geriatrics Society     Volume:  44     ISSN:  0002-8614     ISO Abbreviation:  J Am Geriatr Soc     Publication Date:  1996 Oct 
Date Detail:
Created Date:  1996-11-19     Completed Date:  1996-11-19     Revised Date:  2008-03-10    
Medline Journal Info:
Nlm Unique ID:  7503062     Medline TA:  J Am Geriatr Soc     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1232-4     Citation Subset:  IM    
Department of Medicine, University of Maryland at Baltimore, USA.
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MeSH Terms
Absorptiometry, Photon
Aged, 80 and over
Alzheimer Disease / metabolism*
Basal Metabolism*
Body Composition
Calorimetry, Indirect
Cross-Sectional Studies
Middle Aged
Reference Values
Grant Support

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