Document Detail


No evidence of direct cardiac action of leucine-enkephalin in canine heart-lung preparation.
MedLine Citation:
PMID:  6471614     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Intravenous administration of leucine-enkephalin (30 micrograms/kg) caused significant decreases in mean blood pressure, cardiac output, and left ventricular dP/dt in intact dogs. However, cardiovascular effects of leucine-enkephalin (30-120 micrograms/kg) did not occur in the heart-lung preparation uninfluenced by extracardiopulmonary factors. These results provide no evidence of a direct cardiac action of leucine-enkephalin.
Authors:
S Koyama; N Terada; Y Shiojima; T Takeuchi
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Japanese journal of physiology     Volume:  34     ISSN:  0021-521X     ISO Abbreviation:  Jpn. J. Physiol.     Publication Date:  1984  
Date Detail:
Created Date:  1984-10-15     Completed Date:  1984-10-15     Revised Date:  2007-03-21    
Medline Journal Info:
Nlm Unique ID:  2985184R     Medline TA:  Jpn J Physiol     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  351-5     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Anesthesia, General
Animals
Blood Pressure / drug effects
Cardiac Output / drug effects
Dogs
Enkephalin, Leucine / pharmacology*
Heart / drug effects*
Heart Rate / drug effects
Chemical
Reg. No./Substance:
58822-25-6/Enkephalin, Leucine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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