Document Detail

No evidence of developmental III effects of low-level lead exposure in a developing country.
MedLine Citation:
PMID:  7528225     Owner:  NLM     Status:  MEDLINE    
Despite substantial controversy regarding the blood levels at which lead adversely affects neurobehavioral development, public health policy in some industrialized countries is prescribing ever more stringent screening criteria for all ages. This study addressed the question of ill effects of lead exposure at the new lower levels, specifically during the late infancy period, which has been targeted for maximum surveillance in pediatric practice. The sample of 184 participants consisted of 12- to 23-month-old healthy infants and toddlers who participated in a community-based study in a developing Central American country (Costa Rica) where extensive family and developmental information was collected. The mean infant blood lead level was 11.0 micrograms/dL, ranging from 5.4 to 37.0 micrograms/dL. Lead levels were not related to the Mental or Psychomotor Developmental Index of the Bayley Scales of Infant Development. When the children were 5 years old, they were reevaluated with complete physical and psychological testing. Blood lead levels in infancy did not predict any of the developmental outcome measures. Thus, among a group of healthy toddlers in a developing country, no ill effects on development of low blood lead levels were observed.
A W Wolf; E Jimenez; B Lozoff
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of developmental and behavioral pediatrics : JDBP     Volume:  15     ISSN:  0196-206X     ISO Abbreviation:  J Dev Behav Pediatr     Publication Date:  1994 Aug 
Date Detail:
Created Date:  1995-01-25     Completed Date:  1995-01-25     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8006933     Medline TA:  J Dev Behav Pediatr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  224-31     Citation Subset:  IM    
Department of Psychiatry, Case Western Reserve University, School of Medicine, MetroHealth Medical Center, Cleveland, Ohio.
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MeSH Terms
Anemia, Iron-Deficiency / blood,  classification,  epidemiology
Child, Preschool
Cohort Studies
Costa Rica / epidemiology
Cross-Sectional Studies
Developing Countries*
Developmental Disabilities / chemically induced*,  classification,  epidemiology
Follow-Up Studies
Iron / blood
Lead / pharmacokinetics
Lead Poisoning / classification,  epidemiology*
Neuropsychological Tests
Grant Support
Reg. No./Substance:
7439-89-6/Iron; 7439-92-1/Lead

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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