Document Detail


No evidence of delayed parasite clearance after oral artesunate treatment of uncomplicated falciparum malaria in Mali.
MedLine Citation:
PMID:  22764287     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Plasmodium falciparum resistance to artemisinins by delayed parasite clearance is present in Southeast Asia. Scant data on parasite clearance after artemisinins are available from Africa, where transmission is high, burden is greatest, and artemisinin use is being scaled up. Children 1-10 years of age with uncomplicated malaria were treated with 7 days of artesunate and followed for 28 days. Blood smears were done every 8 hours until negative by light microscopy. Results were compared with a similar study conducted in the same village in 2002-2004. The polymerase chain reaction-corrected cure rate was 100%, identical to 2002-2004. By 24 hours after treatment initiation, 37.0% of participants had cleared parasitemia, compared with 31.9% in 2002-2004 (P = 0.5). The median parasite clearance time was 32 hours. Only one participant still had parasites at 48 hours and no participant presented parasitemia at 72 hours. Artesunate was highly efficacious, with no evidence of delayed parasite clearance. We provide baseline surveillance data for the emergence or dissemination of P. falciparum resistance in sub-Saharan Africa.
Authors:
Amelia W Maiga; Bakary Fofana; Issaka Sagara; Demba Dembele; Antoine Dara; Oumar Bila Traore; Sekou Toure; Kassim Sanogo; Souleymane Dama; Bakary Sidibe; Aminatou Kone; Mahamadou A Thera; Christopher V Plowe; Ogobara K Doumbo; Abdoulaye A Djimde
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The American journal of tropical medicine and hygiene     Volume:  87     ISSN:  1476-1645     ISO Abbreviation:  Am. J. Trop. Med. Hyg.     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-07-05     Completed Date:  2012-09-10     Revised Date:  2013-07-12    
Medline Journal Info:
Nlm Unique ID:  0370507     Medline TA:  Am J Trop Med Hyg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  23-8     Citation Subset:  AIM; IM    
Affiliation:
Malaria Research and Training Center, Department of Epidemiology of Parasitic Diseases, Faculty of Medicine, Pharmacy, and Odonto-stomatology, University of Bamako, Mali. aw70@duke.edu
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MeSH Terms
Descriptor/Qualifier:
Antimalarials / therapeutic use*
Artemisinins / therapeutic use*
Child
Child, Preschool
Female
Humans
Infant
Malaria, Falciparum / drug therapy*,  parasitology
Male
Mali
Parasitemia
Grant Support
ID/Acronym/Agency:
R24 TW007988/TW/FIC NIH HHS
Chemical
Reg. No./Substance:
0/Antimalarials; 0/Artemisinins; 83507-69-1/artesunate
Comments/Corrections
Comment In:
Am J Trop Med Hyg. 2012 Jul;87(1):16-7   [PMID:  22764285 ]

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