| No evidence of delayed parasite clearance after oral artesunate treatment of uncomplicated falciparum malaria in Mali. | |
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MedLine Citation:
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PMID: 22764287 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Plasmodium falciparum resistance to artemisinins by delayed parasite clearance is present in Southeast Asia. Scant data on parasite clearance after artemisinins are available from Africa, where transmission is high, burden is greatest, and artemisinin use is being scaled up. Children 1-10 years of age with uncomplicated malaria were treated with 7 days of artesunate and followed for 28 days. Blood smears were done every 8 hours until negative by light microscopy. Results were compared with a similar study conducted in the same village in 2002-2004. The polymerase chain reaction-corrected cure rate was 100%, identical to 2002-2004. By 24 hours after treatment initiation, 37.0% of participants had cleared parasitemia, compared with 31.9% in 2002-2004 (P = 0.5). The median parasite clearance time was 32 hours. Only one participant still had parasites at 48 hours and no participant presented parasitemia at 72 hours. Artesunate was highly efficacious, with no evidence of delayed parasite clearance. We provide baseline surveillance data for the emergence or dissemination of P. falciparum resistance in sub-Saharan Africa. |
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Authors:
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Amelia W Maiga; Bakary Fofana; Issaka Sagara; Demba Dembele; Antoine Dara; Oumar Bila Traore; Sekou Toure; Kassim Sanogo; Souleymane Dama; Bakary Sidibe; Aminatou Kone; Mahamadou A Thera; Christopher V Plowe; Ogobara K Doumbo; Abdoulaye A Djimde |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The American journal of tropical medicine and hygiene Volume: 87 ISSN: 1476-1645 ISO Abbreviation: Am. J. Trop. Med. Hyg. Publication Date: 2012 Jul |
Date Detail:
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Created Date: 2012-07-05 Completed Date: 2012-09-10 Revised Date: 2013-04-16 |
Medline Journal Info:
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Nlm Unique ID: 0370507 Medline TA: Am J Trop Med Hyg Country: United States |
Other Details:
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Languages: eng Pagination: 23-8 Citation Subset: AIM; IM |
Affiliation:
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Malaria Research and Training Center, Department of Epidemiology of Parasitic Diseases, Faculty of Medicine, Pharmacy, and Odonto-stomatology, University of Bamako, Mali. aw70@duke.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Antimalarials
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therapeutic use* Artemisinins / therapeutic use* Child Child, Preschool Female Humans Infant Malaria, Falciparum / drug therapy*, parasitology Male Mali Parasitemia |
| Grant Support | |
ID/Acronym/Agency:
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R24 TW007988/TW/FIC NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Antimalarials; 0/Artemisinins; 83507-69-1/artesunate |
| Comments/Corrections | |
Comment In:
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Am J Trop Med Hyg. 2012 Jul;87(1):16-7
[PMID:
22764285
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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