| No evidence of chronic cerebrospinal venous insufficiency at multiple sclerosis onset. | |
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MedLine Citation:
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PMID: 21280079 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: An impaired cerebrospinal venous drainage, defined as chronic cerebrospinal venous insufficiency (CCSVI), has been recently hypothesized to be the possible cause of multiple sclerosis (MS). We investigated this hypothesis by studying the occurrence of CCSVI in clinically isolated syndromes (CISs) suggestive of MS. METHODS: Fifty consecutive patients presenting with a CIS and evidence of dissemination in space of the inflammatory lesions (ie, possible MS [pMS]) underwent a detailed diagnostic workup, including extracranial and transcranial venous echo-color Doppler sonography (ECDS-TCDS). Those with CCSVI underwent selective venography. Fifty healthy subjects (HCs) age-matched and gender-matched with pMS patients (HC1); 60 patients with transient global amnesia (TGA); and 60 healthy subjects age-matched and gender-matched with TGA patients (HC2) constituted the control groups and underwent ECDS-TCDS. RESULTS: Mean age of pMS patients was 33.0 ± 8.5 years (range, 14-50); 35 (70%) were female (female:male ratio, 2.3). TCDS was normal in all pMS patients. One or more abnormal ECDS findings were observed in 26 of 50 (52.0%) pMS patients, in 35 of 110 (31·8%) HCs (HC1+HC2), and in 41 of 60 (68.3%) TGA patients. Eight (16%) pMS patients fulfilled the diagnosis of CCSVI. Selective phlebography performed in 7 of these patients (1 denied consent) did not show venous anomalies. INTERPRETATION: Our findings do not support a cause-effect relationship between CCSVI and pMS. Further studies are warranted to clarify whether CCSVI is associated with later disease stages and characterizes the progressive forms of MS. |
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Authors:
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Claudio Baracchini; Paola Perini; Massimiliano Calabrese; Francesco Causin; Francesca Rinaldi; Paolo Gallo |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Annals of neurology Volume: 69 ISSN: 1531-8249 ISO Abbreviation: Ann. Neurol. Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2011-01-31 Completed Date: 2011-03-16 Revised Date: 2011-09-07 |
Medline Journal Info:
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Nlm Unique ID: 7707449 Medline TA: Ann Neurol Country: United States |
Other Details:
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Languages: eng Pagination: 90-9 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 American Neurological Association. |
Affiliation:
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First Neurology Clinic, University Hospital, Padova, Italy. claudiobaracchini@tin.it |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Amnesia / diagnosis, ultrasonography Azygos Vein / pathology, ultrasonography Cerebral Veins / pathology, ultrasonography Cerebrospinal Fluid / physiology Constriction, Pathologic / pathology, ultrasonography Female Humans Jugular Veins / abnormalities, pathology, ultrasonography Magnetic Resonance Imaging Male Middle Aged Multiple Sclerosis / diagnosis, etiology*, ultrasonography Multiple Sclerosis, Relapsing-Remitting / diagnosis, pathology Phlebography / methods, statistics & numerical data Regional Blood Flow Ultrasonography, Doppler, Color Venous Insufficiency / complications*, diagnosis, ultrasonography Vertebral Artery / pathology, ultrasonography |
| Comments/Corrections | |
Comment In:
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Ann Neurol. 2011 Jun;69(6):1062-3; author reply 1063
[PMID:
21681801
]
Ann Neurol. 2011 Jul;70(1):181; author reply 181-2 [PMID: 21674590 ] |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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