Document Detail

No evidence for an association between variants at the gamma-amino-n-butyric acid type A receptor beta2 locus and schizophrenia.
MedLine Citation:
PMID:  17167345     Owner:  NLM     Status:  MEDLINE    
The alpha1/beta2/gamma2-containing heteropentamer is the most abundant gamma-amino-n-butyric acid type A receptor subtype in mammalian brains and the corresponding genes, the GABRA1, GABRB2, and GABRG2 genes, are located in chromosomal region 5q34 that several genome wide scans have implicated as a susceptibility region for schizophrenia. Given this positional and functional evidence, Lo et al. (Mol Psychiatry 2004; 9: 603-608) performed systematic linkage disequilibrium mapping of the GABAAR gene cluster on 5q34 in 130 schizophrenic patients and 170 controls, all of Chinese Han origin. In the single locus and haplotype analyses, single nucleotide polymorphisms in the GABRB2 gene showed highly significant association. The estimated effect caused by GABRB2 varied between odds ratios of 2.27 and 5.12. In order to re-examine their findings, we analyzed the most significantly associated single nucleotide polymorphism in the GABRB2 gene in a sample of 367 patients with schizophrenia and 360 controls, all of German descent. Our sample had a sufficient power to detect the effects described. Neither single marker nor haplotype analysis revealed a significant association with the disease status. Thus, our results do not support the hypothesis that genetic variation at the GABRB2 locus plays a major role in schizophrenic patients of European descent and that such variation would explain the previously observed linkage findings at this chromosomal region.
Rami Abou Jamra; Tim Becker; Norman Klopp; Faten Dahdouh; Thomas G Schulze; Magdalena Gross; Monika Deschner; Christine Schmäl; Thomas Illig; Marcella Rietschel; Peter Propping; Sven Cichon; Markus M Nöthen; Johannes Schumacher
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Psychiatric genetics     Volume:  17     ISSN:  0955-8829     ISO Abbreviation:  Psychiatr. Genet.     Publication Date:  2007 Feb 
Date Detail:
Created Date:  2006-12-14     Completed Date:  2007-04-17     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  9106748     Medline TA:  Psychiatr Genet     Country:  England    
Other Details:
Languages:  eng     Pagination:  43-5     Citation Subset:  IM    
Institute of Human Genetics, Department of Psychiatry, Life & Brain Center, University of Bonn, Bonn, Germany.
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MeSH Terms
Base Sequence
European Continental Ancestry Group / genetics
Genetic Variation*
Polymorphism, Single Nucleotide
Receptors, GABA-A / genetics*
Schizophrenia / genetics*
Reg. No./Substance:
0/GABRB2 protein, human; 0/Receptors, GABA-A

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