Document Detail

No evidence for an association of AChR beta-subunit gene (CHRNB1) with myasthenia gravis.
MedLine Citation:
PMID:  9307231     Owner:  NLM     Status:  MEDLINE    
Using a polymorphic dinucleotide repeat, we have investigated the contribution of the gene encoding the beta-subunit of the muscle acetylcholine receptor (CHRNB1), the target autoantigen, to the susceptibility to myasthenia gravis (MG). We have combined a case-control study (comparing 143 patients and 162 controls) and a transmission-disequilibrium test bearing on 35 simplex families with heterozygous parents. There was no evidence for an association of CHRNB1 with MG, even after subgrouping patients according to thymus histology, or other clinical criteria. Interestingly however, the shortest four variants of the CHRNB1 microsatellite were seen only in patients with thymus hyperplasia and in none of the control subjects (P < 0.0025).
F Djabiri; P Gajdos; B Eymard; L Gomez; J F Bach; H J Garchon
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of neuroimmunology     Volume:  78     ISSN:  0165-5728     ISO Abbreviation:  J. Neuroimmunol.     Publication Date:  1997 Sep 
Date Detail:
Created Date:  1997-10-15     Completed Date:  1997-10-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8109498     Medline TA:  J Neuroimmunol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  86-9     Citation Subset:  IM    
INSERM U25, Paris, France.
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MeSH Terms
Case-Control Studies
Dinucleotide Repeats / genetics
Microsatellite Repeats
Myasthenia Gravis / genetics*
Polymorphism, Genetic
Receptors, Cholinergic / genetics*
Reference Values
Reg. No./Substance:
0/Receptors, Cholinergic

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