Document Detail

No effects of n-3 fatty acid supplementation on serum total testosterone levels in older men: the Alpha Omega Trial.
MedLine Citation:
PMID:  22394170     Owner:  NLM     Status:  MEDLINE    
The intake of the n-3 fatty acids alpha-linolenic acid (ALA), acid (EPA) and docosahexaenoic acid (DHA) has been related to testosterone levels in epidemiological analyses. The aim of this study was to assess whether the n-3 fatty acids affects testosterone levels in post-myocardial infarction (MI) patients, who are at risk of testosterone deficiency. In a double-blind, placebo-controlled trial of low-dose supplementation of n-3 fatty acids, we included 1850 male post-MI patients aged 60-80 years who participated in the Alpha Omega Trial. Patients were randomly allocated to margarines that provided 400 mg/day of EPA-DHA (n = 453), 2 mg/day of ALA (n = 467), EPA-DHA plus ALA (n = 458), or placebo (n = 472). Serum testosterone levels were assessed at baseline and after 41 months using whole day blood samples obtained at the subjects' home or at the hospital. Subjects were on average age of 68.4 (SD 5.3) years old and had baseline mean serum total testosterone of 14.8 (SD 5.6) nmol/L. The four randomized groups did not differ for baseline characteristics. ALA, EPA-DHA, and EPA-DHA plus ALA supplementation did not affect serum total testosterone compared to placebo. Moreover, n-3 fatty acid supplementation did not affect the risk of incident testosterone deficiency (n = 76 with total testosterone <8.0 nmol/L). We conclude that n-3 fatty acids supplementation did not affect serum total testosterone in men who had had a MI.
E J Giltay; J M Geleijnse; A C Heijboer; J de Goede; L M Oude Griep; M A Blankenstein; D Kromhout
Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2012-03-06
Journal Detail:
Title:  International journal of andrology     Volume:  35     ISSN:  1365-2605     ISO Abbreviation:  Int. J. Androl.     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-09-12     Completed Date:  2013-01-22     Revised Date:  2013-10-17    
Medline Journal Info:
Nlm Unique ID:  8000141     Medline TA:  Int J Androl     Country:  England    
Other Details:
Languages:  eng     Pagination:  680-7     Citation Subset:  IM    
Copyright Information:
© 2012 The Authors. International Journal of Andrology © 2012 European Academy of Andrology.
Department of Psychiatry, Leiden University Medical Center, Leiden, The Netherlands.
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MeSH Terms
Aged, 80 and over
Dietary Supplements
Double-Blind Method
Fatty Acids, Omega-3 / administration & dosage*
Middle Aged
Myocardial Infarction / drug therapy
Testosterone / blood*,  deficiency
Grant Support
Reg. No./Substance:
0/Fatty Acids, Omega-3; 58-22-0/Testosterone; 8029-82-1/Margarine

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