| No effect of short-term arginine supplementation on nitric oxide production, metabolism and performance in intermittent exercise in athletes. | |
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MedLine Citation:
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PMID: 18708287 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Arginine supplementation has been shown to alleviate endothelial dysfunction and improve exercise performance through increasing nitric oxide production in patients with cardiopulmonary diseases. In addition, arginine supplementation could decrease accumulations of lactate and ammonia, metabolites involved in development of muscular fatigue. The aim of this study was to investigate the effect of short-term arginine supplementation on performance in intermittent anaerobic exercise and the underlying mechanism in well-trained male athletes. Ten elite male college judo athletes participated with a randomized crossover, placebo-controlled design. The subjects consumed 6 g/day arginine (ARG trial) or placebo (CON trial) for 3 days then performed an intermittent anaerobic exercise test on a cycle ergometer. Blood samples were collected before supplementation, before and during exercise and 0, 3, 6, 10, 30 and 60 min after exercise. ARG trial had significantly higher arginine concentrations than CON trial at the same time point before, during and after exercise. In both trials, nitrate and nitrite concentration was significantly higher during and 6 min after exercise comparing to the basal concentration. The increase in nitrate and nitrite concentration during exercise in both trials was parallel to the increase in plasma citrulline concentrations. There was no significant difference between the 2 trials in plasma nitrate and nitrite, lactate and ammonia concentrations and peak and average power in the exercise. The results of this study suggested that short-term arginine supplementation had no effect on nitric oxide production, lactate and ammonia metabolism and performance in intermittent anaerobic exercise in well-trained male athletes. |
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Authors:
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Tsung-Han Liu; Ching-Lin Wu; Chi-Wei Chiang; Yu-Wei Lo; Hung-Fu Tseng; Chen-Kang Chang |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't Date: 2008-08-15 |
Journal Detail:
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Title: The Journal of nutritional biochemistry Volume: 20 ISSN: 1873-4847 ISO Abbreviation: J. Nutr. Biochem. Publication Date: 2009 Jun |
Date Detail:
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Created Date: 2009-05-15 Completed Date: 2009-10-22 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9010081 Medline TA: J Nutr Biochem Country: United States |
Other Details:
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Languages: eng Pagination: 462-8 Citation Subset: IM |
Affiliation:
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Department of Physical Education, Taiwan Sport University, 404 Taichung, Taiwan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Ammonia
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blood Arginine / administration & dosage* Citrulline / blood Cross-Over Studies Exercise / physiology* Humans Lactates / blood Male Martial Arts / physiology Nitric Oxide / biosynthesis* Placebos Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Lactates; 0/Placebos; 10102-43-9/Nitric Oxide; 372-75-8/Citrulline; 74-79-3/Arginine; 7664-41-7/Ammonia |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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