| No effect of maternal micronutrient supplementation on early childhood growth in rural western China: 30 month follow-up evaluation of a double blind, cluster randomized controlled trial. | |
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MedLine Citation:
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PMID: 22085869 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Background/Objectives:Little is known about the long-term effects of maternal multi-micronutrient supplementation on the growth of children during early childhood. In this follow-up study, the effects of maternal supplementation with multi-micronutrients in pregnancy on postnatal child growth are examined.Subjects/Methods:A longitudinal follow-up of a subset of newborns (n=1388) whose mothers were randomly assigned to receive the supplements of folic acid, iron-folic acid or multi-micronutrients daily during pregnancy in the original trial was conducted. Children's weight and length were measured and assessed during monthly home visits from birth to 30 months of age.Results:The pooled prevalence rate of stunting over different time points during the first 30 months was 13.5, 14.9 and 12.1% for the folic acid group, iron-folic acid group and multi-micronutrient group, respectively. However, there were no significant differences in the pooled odds of stunting in children between the multi-micronutrient group and the folic acid (odds ratio (OR) 0.97, 95% confidence interval (CI): 0.74-1.26), and between the multi-micronutrient group and the iron-folic acid group (OR 0.82, 95% CI: 0.63-1.07). Similar results for the three groups were found for the occurrences of underweight and wasting in children. Furthermore, no significant differences were observed in length, weight, length-for-age, weight-for-age and weight-for-length Z-scores among the three treatment groups.Conclusions:Currently, available evidence is insufficient to support a greater advantage of the effect of maternal multi-micronutrient supplementation on child growth over iron-folic acid or folic acid only supplementation during the first 30 months.European Journal of Clinical Nutrition advance online publication, 16 November 2011; doi:10.1038/ejcn.2011.190. |
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Authors:
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W Wang; H Yan; L Zeng; Y Cheng; D Wang; Q Li |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-11-16 |
Journal Detail:
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Title: European journal of clinical nutrition Volume: - ISSN: 1476-5640 ISO Abbreviation: - Publication Date: 2011 Nov |
Date Detail:
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Created Date: 2011-11-16 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8804070 Medline TA: Eur J Clin Nutr Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Public Health, Xi'an Jiaotong University College of Medicine, Xi'an, China. |
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