| No effect of glutamine ingestion on indices of oxidative metabolism in stable COPD. | |
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MedLine Citation:
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PMID: 21419239 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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COPD patients have reduced muscle glutamate which may contribute to an impaired response of oxidative metabolism to exercise. We hypothesised that prior glutamine supplementation would enhance V(o2) peak, V(o2) at lactate threshold and speed pulmonary oxygen uptake kinetics in COPD. 13 patients (9 male, age 66±5years, mean±SD) with severe COPD (Mean FEV(1) 0.88±0.23L, 33±7% predicted) performed on separate days ramp cycle-ergometry (5-10W.min(-1)) to volitional exhaustion and subsequently square-wave transitions to 80% estimated lactate threshold (LT) following consumption of either placebo (CON) or 0.125g.kg bm(-1) of glutamine (GLN) in 5ml.kg bm(-1) placebo. Oral glutamine had no effect on peak or V(o2) at LT, {V(o2) peak: CON=0.70±0.1 vs. GLN=0.73±0.2 l.min(-1); LT: CON=0.57±0.1 vs. GLN=0.54±0.1 l.min(-1)} or V(o2) kinetics {tau: CON=68±22 vs. GLN=68±16s}. Ingestion of glutamine before exercise did not improve indices of oxidative metabolism in this patient group. |
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Authors:
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Simon Marwood; Sandy Jack; Mukhtar Patel; Paul Walker; Joanna Bowtell; Peter Calverley |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-3-15 |
Journal Detail:
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Title: Respiratory physiology & neurobiology Volume: - ISSN: 1878-1519 ISO Abbreviation: - Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-3-22 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101140022 Medline TA: Respir Physiol Neurobiol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011. Published by Elsevier B.V. |
Affiliation:
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Health & Applied Social Sciences, Liverpool Hope University, Liverpool, UK, L16 9JD. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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