Document Detail


No effect of exercise on urinary 6-sulfatoxymelatonin and catecholamines in young women participating in a 16-week randomized controlled trial.
MedLine Citation:
PMID:  23861293     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Women with breast cancer have decreased levels of melatonin or its metabolite in plasma and/or urine.
METHODS: We measured serum melatonin, urinary 6-sulfatoxymelatonin, catecholamines, and cortisol in 141 sedentary young female participants in a clinical trial comparing 150 min/wk aerobic exercise for 4 months to no-exercise controls. Demographics, health surveys, body composition, sleep quality, fitness levels, and blood and urine samples were obtained at baseline and 16 weeks.
RESULTS: There were no differences between groups at baseline in demographics, exercise, sleep habits, or study hormones. There were also no significant differences between groups in any of the hormones at 16 weeks.
CONCLUSION: Sixteen weeks of exercise had minimal effects on melatonin secretion of young women.
IMPACT: There is convincing evidence that exercise protects against breast cancer, but this does not appear to occur through changes in melatonin secretion.
Authors:
Andrea Y Arikawa; William Thomas; Sanjay R Patel; Mindy S Kurzer
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural     Date:  2013-07-16
Journal Detail:
Title:  Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology     Volume:  22     ISSN:  1538-7755     ISO Abbreviation:  Cancer Epidemiol. Biomarkers Prev.     Publication Date:  2013 Sep 
Date Detail:
Created Date:  2013-09-09     Completed Date:  2014-06-11     Revised Date:  2014-09-02    
Medline Journal Info:
Nlm Unique ID:  9200608     Medline TA:  Cancer Epidemiol Biomarkers Prev     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1634-6     Citation Subset:  IM    
Copyright Information:
©2013 AACR.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Breast Neoplasms / blood,  prevention & control,  secretion,  urine*
Catecholamines / blood,  urine*
Enzyme-Linked Immunosorbent Assay
Exercise / physiology*
Female
Humans
Melatonin / analogs & derivatives*,  blood,  secretion,  urine
Young Adult
Grant Support
ID/Acronym/Agency:
M01-RR00400/RR/NCRR NIH HHS; R21 CA137242/CA/NCI NIH HHS; R21 CA137242/CA/NCI NIH HHS
Chemical
Reg. No./Substance:
0/Catecholamines; 2208-40-4/6-sulfatoxymelatonin; JL5DK93RCL/Melatonin
Comments/Corrections

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