Document Detail

No effect of exercise on insulin-like growth factor-I, insulin, and glucose in young women participating in a 16-week randomized controlled trial.
MedLine Citation:
PMID:  20833973     Owner:  NLM     Status:  MEDLINE    
INTRODUCTION: Insulin-like growth factor I (IGF-I) and IGF binding protein 3 (IGFBP-3) have been associated with increased risk of breast cancer.
METHODS: We report our findings on the effects of 16 weeks of aerobic exercise on IGF axis proteins, insulin, glucose, and insulin resistance of 319 young sedentary women. Demographics, health surveys, body composition, dietary intake, and blood samples were collected at baseline and 16 weeks. IGF-I and IGFBP-1, IGFBP-2, and IGFBP-3 were measured by ELISA.
RESULTS: Exercise adherence was 88%. The dropout rates for the exercise and control groups were 21.7% and 14.5%, respectively. There was a small significant change from baseline in IGFBP-3 concentrations. IGFBP-3 levels decreased in controls and increased in exercisers. The between-group difference was significant. No other changes were noted.
CONCLUSION: Sixteen weeks of exercise had minimum or no effect on IGF proteins of young women.
IMPACT: Our study supports findings from previous studies conducted in older populations and raises the question of what type of intervention is needed to change circulating levels of IGF proteins in humans.
Andrea Y Arikawa; Mindy S Kurzer; William Thomas; Kathryn H Schmitz
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural     Date:  2010-09-10
Journal Detail:
Title:  Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology     Volume:  19     ISSN:  1538-7755     ISO Abbreviation:  Cancer Epidemiol. Biomarkers Prev.     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-11-09     Completed Date:  2011-02-22     Revised Date:  2014-09-24    
Medline Journal Info:
Nlm Unique ID:  9200608     Medline TA:  Cancer Epidemiol Biomarkers Prev     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2987-90     Citation Subset:  IM    
Copyright Information:
©2010 AACR.
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MeSH Terms
Blood Glucose / analysis*,  metabolism
Breast Neoplasms / blood,  prevention & control*
Enzyme-Linked Immunosorbent Assay
Exercise / physiology*
Insulin / blood*
Insulin-Like Growth Factor Binding Protein 1 / blood
Insulin-Like Growth Factor Binding Protein 2 / blood
Insulin-Like Growth Factor Binding Protein 3 / blood
Insulin-Like Growth Factor I / analysis*,  metabolism
Young Adult
Grant Support
M01-RR00400/RR/NCRR NIH HHS; R01 CA131333/CA/NCI NIH HHS; U54 CA116849/CA/NCI NIH HHS; U54 CA116849/CA/NCI NIH HHS; U54 CA155850/CA/NCI NIH HHS
Reg. No./Substance:
0/Blood Glucose; 0/Insulin; 0/Insulin-Like Growth Factor Binding Protein 1; 0/Insulin-Like Growth Factor Binding Protein 2; 0/Insulin-Like Growth Factor Binding Protein 3; 67763-96-6/Insulin-Like Growth Factor I

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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