Document Detail


No effect of exercise on colon mucosal prostaglandin concentrations: a 12-month randomized controlled trial.
MedLine Citation:
PMID:  18006923     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Epidemiologic studies provide evidence that exercise is associated with reduced risk of colon cancer. Exercise may exert protective effects on the colon by influencing prostaglandin production. We hypothesized that an exercise intervention would decrease prostaglandin E(2) concentrations and increase prostaglandin F(2alpha) in colon biopsies compared with controls. METHODS: A 12-month randomized controlled trial testing the effects of exercise on colon mucosal prostaglandin concentrations was conducted in men (n=95) and women (n=89). The exercise intervention included moderate-to-vigorous aerobic activity, 60 min/d, 6 days/wk versus controls. Prostaglandin E(2) and F(2alpha) concentrations were measured in colon biopsies using an enzyme-linked immunoassay at baseline and at 12 months to assess changes in mean concentration for each group. RESULTS: Baseline colon prostaglandin E(2) and F(2alpha) concentrations were not correlated with age, race, education, family history of colon cancer, previous polyps, body size, diet, smoking, nonsteroidal antiinflammatory drug use, metabolic factors, or sex hormone levels. For both men and women, the exercise and control groups showed no change in mean prostaglandin E(2) or F(2alpha) between the baseline and 12-month biopsies. There was no difference in mean prostaglandin concentrations between exercisers and controls when exercisers were grouped by level of intervention adherence. Results were not modified by baseline age, body mass index, percentage of body fat, nonsteroidal antiinflammatory drug use, history of adenomatous polyps, or family history of colon cancer. CONCLUSION: A 12-month moderate-to-vigorous intensity aerobic exercise intervention did not result in significant changes in colon mucosal prostaglandin concentrations.
Authors:
Page E Abrahamson; Irena B King; Cornelia M Ulrich; Rebecca E Rudolph; Melinda L Irwin; Yutaka Yasui; Christina Surawicz; Johanna W Lampe; Paul D Lampe; Angela Morgan; Bess E Sorensen; Kamran Ayub; John D Potter; Anne McTiernan
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology     Volume:  16     ISSN:  1055-9965     ISO Abbreviation:  Cancer Epidemiol. Biomarkers Prev.     Publication Date:  2007 Nov 
Date Detail:
Created Date:  2007-11-16     Completed Date:  2008-05-16     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9200608     Medline TA:  Cancer Epidemiol Biomarkers Prev     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2351-6     Citation Subset:  IM    
Affiliation:
Cancer Prevention, Fred Hutchinson Cancer Research Center, Seattle, WA 98109-1024, USA.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Colon, Sigmoid / metabolism*
Dinoprost / metabolism*
Dinoprostone / metabolism*
Double-Blind Method
Exercise / physiology*
Female
Humans
Intestinal Mucosa / metabolism*
Male
Middle Aged
Grant Support
ID/Acronym/Agency:
AG1094/AG/NIA NIH HHS; M01-RR-00037/RR/NCRR NIH HHS; R01 CA77572/CA/NCI NIH HHS; R25 CA94880/CA/NCI NIH HHS
Chemical
Reg. No./Substance:
363-24-6/Dinoprostone; 551-11-1/Dinoprost

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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