| No differences in mucosal adaptive growth one week after intestinal resection in rats given enteral glutamine supplementation or deprived of glutamine. | |
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MedLine Citation:
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PMID: 8817227 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To evaluate the effects of intraluminal glutamine on the adaptation of intestinal mucosa after resection compared with transsection and un-operated on control animals. DESIGN: Open, controlled, experimental study. SETTING: University hospital, Sweden. SUBJECTS: 123 Sprague-Dawley rats. INTERVENTION: Daily isonitrogenous oral diet was given either free of glutamine or supplemented with 4% glutamine for 2 or 7 days to rats subjected to intestinal resection, transection or no operation. MAIN OUTCOME MEASURES: Body weight and protein content, DNA content, and thymidine incorporation in jejunal and ileal mucosa. RESULTS: Resection resulted in a significant growth stimulation evaluated by weight/body weight, protein, and DNA content (p < 0.05-0.001). Glutamine supplementation did not significantly influence this growth response. Thymidine incorporation in jejunum was stimulated by glutamine on day 3 (p < 0.05-0.001). CONCLUSION: The glutamine fortified diet had no growth stimulating effects compared with a glutamine free diet one week after 60% intestinal resection. An early increase in thymidine incorporation indicated that glutamine had a transient proliferative effect. |
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Authors:
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M E Wirén; J Permert; S P Skullman; F Wang; J Larsson |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The European journal of surgery = Acta chirurgica Volume: 162 ISSN: 1102-4151 ISO Abbreviation: Eur J Surg Publication Date: 1996 Jun |
Date Detail:
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Created Date: 1996-12-05 Completed Date: 1996-12-05 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9105264 Medline TA: Eur J Surg Country: NORWAY |
Other Details:
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Languages: eng Pagination: 489-98 Citation Subset: IM |
Affiliation:
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Department of Surgery, Faculty of Health Sciences, University of Linköping, Sweden. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adaptation, Physiological* Administration, Oral Animals Body Weight Cell Division DNA / metabolism Glutamine / administration & dosage, pharmacology* Ileum / cytology, metabolism Intestinal Mucosa / cytology* Intestine, Small / surgery* Jejunum / cytology, metabolism Male Proteins / metabolism Rats Rats, Sprague-Dawley Thymidine / metabolism Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Proteins; 50-89-5/Thymidine; 56-85-9/Glutamine; 9007-49-2/DNA |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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