Document Detail

No difference in platelet activation or inflammation markers after diets rich or poor in vegetables, berries and apple in healthy subjects.
MedLine Citation:
PMID:  15168040     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: High intake of vegetables and fruits is associated with decreased risk of coronary heart disease. Part of these cardioprotective effects may be mediated via the antithrombotic effects of compounds found in vegetables and fruits, such as flavonoids. AIM OF THE STUDY: To study the effects of high and low intake of vegetables, berries and apple on platelet function and inflammatory markers. METHODS: The study was a randomised, controlled parallel human dietary intervention with healthy female and male volunteers (n = 77, 19-52 y). Nineteen healthy volunteers served as controls. The volunteers consumed one of four strictly controlled isocaloric 6-week diets containing either 810 or 196 g/10 MJ of vegetables, berries and apple and rich either in linoleic acid (11% of energy, en%) or oleic acid (12 en%). Blood and three 24-hour urine samples were collected at the beginning and at the end of the study period for analyses of various markers of platelet function and inflammation. RESULTS: No differences between the treatment groups were seen in platelet count or volume, markers of platelet activation ( ex vivo aggregation to ADP and thrombin receptor activating peptide, protein kinase C activity, urinary 2,3-dinor-thromboxane B2 excretion, plasma P-selectin), plasma intercellular adhesion molecule-1, sensitive C-reactive protein, or antiphospholipid antibodies. CONCLUSIONS: The results indicate that in healthy volunteers 6-week diets differing markedly in the amounts of vegetables, berries and apple do not differ in their effects on platelets or inflammation.
Riitta Freese; Outi Vaarala; Anu M Turpeinen; Marja Mutanen
Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't     Date:  2004-01-06
Journal Detail:
Title:  European journal of nutrition     Volume:  43     ISSN:  1436-6207     ISO Abbreviation:  Eur J Nutr     Publication Date:  2004 Jun 
Date Detail:
Created Date:  2004-05-28     Completed Date:  2004-10-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  100888704     Medline TA:  Eur J Nutr     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  175-82     Citation Subset:  IM    
Dept. of Applied Chemistry and Microbiology (Nutrition), PO Box 27 (Viikki, Latokartanonkaari 9), 00014 University of Helsinki, Finland.
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MeSH Terms
Biological Markers / blood,  urine
Coronary Disease / epidemiology,  etiology
Fruit* / chemistry
Inflammation / blood*,  urine*
Linoleic Acid / administration & dosage
Malus* / chemistry
Middle Aged
Oleic Acid / administration & dosage
Platelet Activation / drug effects*
Vegetables* / chemistry
Reg. No./Substance:
0/Biological Markers; 112-80-1/Oleic Acid; 2197-37-7/Linoleic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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