| No difference in net uptake or disposal of lactate by trained and untrained forearms during incremental sodium lactate infusion. | |
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MedLine Citation:
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PMID: 11606009 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A number of training adaptations in skeletal muscle might be expected to enhance lactate extraction during hyperlactataemia. The aim of the present study was to determine whether resting endurance-trained forearms exhibit an increased net lactate removal during hyperlactataemia. Six racquet-sport players attended the laboratory for two experiments, separated by 2 weeks. In the first experiment incremental handgrip exercise to fatigue was performed to identify trained (TRFA, n = 6) and untrained (UTFA, n = 5) forearms. In the second experiment net forearm lactate exchange was compared between TRFA and UTFA during an incremental infusion of sodium lactate. TRFA performed more work than UTFA during handgrip exercise [mean (SE) TRFA, 66.1 (9.5) J.100 ml(-1); UTFA, 35.1 (2.3) J.100 ml(-1); P = 0.02] and UTFA exhibited a greater increase in net lactate output relative to work load (P = 0.003). During lactate infusion net lactate uptake across the resting forearms increased linearly with the arterial lactate concentration in both groups (TRFA, r = -0.95 (0.03); UTFA, r= -0.92 (0.04); P < 0.02], with no difference in the regression slopes [TRFA, -1.06 (0.13); UTFA, -1.07 (0.27); P = 0.97] or y-intercepts [TRFA, 0.67 (0.20); UTFA, 1.36 (0.67); P = 0.37] between groups. Almost all of the lactate taken up was disposed of by both groups of forearms [TRFA, 99.6 (0.2)%; UTFA, 98.5 (1.0)%; P = 0.37]. It was concluded that the net uptake and removal of lactate by resting skeletal muscle is a function of the concentration of lactate in the blood perfusing the muscle rather than the muscle training status. |
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Authors:
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J D Buckley; G C Scroop; P G Catcheside |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article |
Journal Detail:
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Title: European journal of applied physiology Volume: 85 ISSN: 1439-6319 ISO Abbreviation: Eur. J. Appl. Physiol. Publication Date: 2001 Sep |
Date Detail:
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Created Date: 2001-10-18 Completed Date: 2002-03-12 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 100954790 Medline TA: Eur J Appl Physiol Country: Germany |
Other Details:
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Languages: eng Pagination: 412-9 Citation Subset: IM |
Affiliation:
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Centre for Research in Education and Sports Science, University of South Australia, Underdale. j.buckley@unisa.edu.au |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Exercise / physiology* Forearm / physiology* Hand Strength / physiology Humans Male Muscle, Skeletal / blood supply, metabolism Racquet Sports / physiology Regional Blood Flow / physiology Sodium Lactate / blood, pharmacokinetics* |
| Chemical | |
Reg. No./Substance:
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72-17-3/Sodium Lactate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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