Document Detail

No detection of human bocavirus in amniotic fluid samples from fetuses with hydrops or isolated effusions.
MedLine Citation:
PMID:  19473872     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Human bocavirus (HBoV) is a recently identified parvovirus associated with respiratory disease in infants. Animal bocaviruses have been shown to cause intrauterine infection, fetal anasarca and abortion in late gestation. OBJECTIVES: To investigate whether HBoV infection is associated with fetal hydrops, fetal anemia or isolated fetal effusions. STUDY DESIGN: We determined the prevalence of HBoV and parvovirus B19 (B19) DNA in amniotic fluid samples from fetuses with hydrops, anemia or isolated effusions using different real-time PCR protocols, and the HBoV IgG and IgM positivity rate in pregnant women with fetal hydrops or normal ultrasound findings by a non-commercial virus-like particle-based enzyme immunoassay. RESULTS: None of 87 amniotic fluid samples tested was HBoV DNA positive. Twelve of 60 fetuses with hydrops or anemia were found B19 DNA positive. Anti-HBoV IgG antibodies were detected in 100% (19/19) and 94% (47/50) of serum samples from pregnant women with fetal hydrops and normal ultrasound findings, respectively. All serum samples were found negative for anti-HBoV IgM. CONCLUSION: We suggest that HBoV is not a common cause of fetal hydrops, anemia or isolated effusions. This has to be confirmed by further studies of proven gestational HBoV infection.
Martin Enders; Juha Lindner; Jürgen J Wenzel; Carola Baisch; Gunnar Schalasta; Gisela Enders; Susanne Modrow
Publication Detail:
Type:  Journal Article     Date:  2009-05-26
Journal Detail:
Title:  Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology     Volume:  45     ISSN:  1873-5967     ISO Abbreviation:  J. Clin. Virol.     Publication Date:  2009 Aug 
Date Detail:
Created Date:  2009-07-13     Completed Date:  2009-09-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9815671     Medline TA:  J Clin Virol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  300-3     Citation Subset:  IM    
Laboratory Prof. Enders and Partners & Institute of Virology, Infectious Diseases and Epidemiology, Rosenbergstrasse 85, D-70193 Stuttgart, Germany.
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MeSH Terms
Amniotic Fluid / virology*
Anemia / virology*
Antibodies, Viral / blood
Bocavirus / isolation & purification*
Edema / virology*
Fetal Diseases / virology*
Fetus / virology*
Immunoglobulin G / blood
Immunoglobulin M / blood
Parvoviridae Infections / virology*
Parvovirus B19, Human / isolation & purification
Polymerase Chain Reaction / methods
Pregnancy Complications, Infectious / virology
Reg. No./Substance:
0/Antibodies, Viral; 0/Immunoglobulin G; 0/Immunoglobulin M

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