| No detection of human bocavirus in amniotic fluid samples from fetuses with hydrops or isolated effusions. | |
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MedLine Citation:
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PMID: 19473872 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Human bocavirus (HBoV) is a recently identified parvovirus associated with respiratory disease in infants. Animal bocaviruses have been shown to cause intrauterine infection, fetal anasarca and abortion in late gestation. OBJECTIVES: To investigate whether HBoV infection is associated with fetal hydrops, fetal anemia or isolated fetal effusions. STUDY DESIGN: We determined the prevalence of HBoV and parvovirus B19 (B19) DNA in amniotic fluid samples from fetuses with hydrops, anemia or isolated effusions using different real-time PCR protocols, and the HBoV IgG and IgM positivity rate in pregnant women with fetal hydrops or normal ultrasound findings by a non-commercial virus-like particle-based enzyme immunoassay. RESULTS: None of 87 amniotic fluid samples tested was HBoV DNA positive. Twelve of 60 fetuses with hydrops or anemia were found B19 DNA positive. Anti-HBoV IgG antibodies were detected in 100% (19/19) and 94% (47/50) of serum samples from pregnant women with fetal hydrops and normal ultrasound findings, respectively. All serum samples were found negative for anti-HBoV IgM. CONCLUSION: We suggest that HBoV is not a common cause of fetal hydrops, anemia or isolated effusions. This has to be confirmed by further studies of proven gestational HBoV infection. |
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Authors:
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Martin Enders; Juha Lindner; Jürgen J Wenzel; Carola Baisch; Gunnar Schalasta; Gisela Enders; Susanne Modrow |
Publication Detail:
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Type: Journal Article Date: 2009-05-26 |
Journal Detail:
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Title: Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology Volume: 45 ISSN: 1873-5967 ISO Abbreviation: J. Clin. Virol. Publication Date: 2009 Aug |
Date Detail:
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Created Date: 2009-07-13 Completed Date: 2009-09-02 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9815671 Medline TA: J Clin Virol Country: Netherlands |
Other Details:
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Languages: eng Pagination: 300-3 Citation Subset: IM |
Affiliation:
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Laboratory Prof. Enders and Partners & Institute of Virology, Infectious Diseases and Epidemiology, Rosenbergstrasse 85, D-70193 Stuttgart, Germany. mender@labor-enders.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Amniotic Fluid / virology* Anemia / virology* Animals Antibodies, Viral / blood Bocavirus / isolation & purification* Edema / virology* Female Fetal Diseases / virology* Fetus / virology* Humans Immunoglobulin G / blood Immunoglobulin M / blood Parvoviridae Infections / virology* Parvovirus B19, Human / isolation & purification Polymerase Chain Reaction / methods Pregnancy Pregnancy Complications, Infectious / virology Prevalence |
| Chemical | |
Reg. No./Substance:
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0/Antibodies, Viral; 0/Immunoglobulin G; 0/Immunoglobulin M |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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