Document Detail

No compensatory upregulation of placental dimethylarginine dimethylaminohydrolase activity in preeclampsia.
MedLine Citation:
PMID:  16508323     Owner:  NLM     Status:  MEDLINE    
BACKGROUND/AIMS: Placental dysfunction of the asymmetric dimethylarginine (ADMA) degrading enzyme dimethylarginine dimethylaminohydrolase (DDAH) has been suggested as one of the initiating events in the development of preeclampsia (PE). Our primary aim was to investigate the role of the placenta in the metabolism of ADMA during normal pregnancy and PE. METHODS: We studied 27 nonpregnant healthy women (C), 15 normotensive pregnant females (P), 16 patients with PE, and 7 patients with the 'hemolysis, elevated liver enzymes and low platelets' syndrome (H). RESULTS: There were no significant differences between P and PE with respect to fetomaternal gradient of ADMA, placental DDAH activity and placental ADMA content. During the first stage of labour, mean (+/-SD) plasma ADMA (micromol/l) was higher in H (0.69 +/- 0.22; p < 0.05) compared with C (0.44 +/- 0.07), P (0.37 +/- 0.06), and PE (0.40 +/- 0.06). ADMA was significantly associated with laboratory parameters of hepatic and renal function and with clinical parameters, including systolic and diastolic blood pressure, gestational age, birth weight, and placenta weight. CONCLUSIONS: A compensatory upregulation of placental DDAH activity is absent in patients suffering from PE and levels of ADMA in plasma and placenta are normal in patients suffering from PE. However, when the course of PE deteriorates and organ dysfunction (especially liver and kidney) becomes involved, such as during the hemolysis, elevated liver enzymes and low platelets syndrome, ADMA levels increase.
Michiel P C Siroen; Tom Teerlink; Antoinette C Bolte; Ruurd M van Elburg; Milan C Richir; Robert J Nijveldt; Ben van der Hoven; Paul A M van Leeuwen
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Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2006-02-27
Journal Detail:
Title:  Gynecologic and obstetric investigation     Volume:  62     ISSN:  0378-7346     ISO Abbreviation:  Gynecol. Obstet. Invest.     Publication Date:  2006  
Date Detail:
Created Date:  2006-07-03     Completed Date:  2006-12-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7900587     Medline TA:  Gynecol Obstet Invest     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  7-13     Citation Subset:  IM    
Copyright Information:
2006 S. Karger AG, Basel
Department of Surgery, VU University Medical Center, Amsterdam, The Netherlands.
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MeSH Terms
Amidohydrolases / blood*
Case-Control Studies
HELLP Syndrome / blood,  physiopathology
Netherlands / epidemiology
Placenta / enzymology*
Pre-Eclampsia / blood*,  physiopathology
Pregnancy / blood*,  physiology
Prospective Studies
Reg. No./Substance:
EC 3.5.-/Amidohydrolases; EC

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