| No circulating cytomegalovirus in five patients with glioblastoma multiforme. | |
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MedLine Citation:
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PMID: 21498720 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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BACKGROUND: Glioblastoma multiforme is the most common and most aggressive type of primary brain tumor, accounting for 52% of all primary brain tumor cases and 20% of all intracranial tumors. Recently, evidence for a viral cause has been postulated, possibly SV40 or more likely cytomegalovirus (CMV). One report indicated that 80% of patients with newly diagnosed glioblastoma multiforme have detectable cytomegalovirus DNA in their peripheral blood, while sero-positive normal donors and other surgical patients did not exhibit detectable virus. PATIENTS AND METHODS: In the current study, we examined peripheral blood of 5 patients with newly diagnosed glioblastoma multiforme. Peripheral blood was collected in anticoagulated tubes from five patients with newly diagnosed glioblastoma multiforme referred for radiation therapy. We used standard methods for detecting CMV by reverse transcriptase-polymerase chain reaction (RT-PCR) and peripheral blood culture. RESULTS: None of our patients had circulating CMV. CONCLUSION: There are four subtypes of glioblastoma. We hypothesize that circulating CMV might be limited to some, but not all of these subtypes, and that our failure to detect CMV might be attributed to the fact that none of these patients had the appropriate subtype or subtypes. |
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Authors:
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Steven Lehrer; Vincent Labombardi; Sheryl Green; Melissa S Pessin-Minsley; Isabelle M Germano; Kenneth E Rosenzweig |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Anticancer research Volume: 31 ISSN: 1791-7530 ISO Abbreviation: Anticancer Res. Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-04-18 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8102988 Medline TA: Anticancer Res Country: Greece |
Other Details:
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Languages: eng Pagination: 959-60 Citation Subset: IM |
Affiliation:
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Mount Sinai Medical Center, Box 1236, New York 10029, U.S.A. stevenlehrer@hotmail.com. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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