Document Detail

No changes in central quinolinic acid levels in Alzheimer's disease.
MedLine Citation:
PMID:  2535006     Owner:  NLM     Status:  MEDLINE    
Levels of the endogenous excitotoxin quinolinic acid were measured in brain and lumbar spinal fluid from Alzheimer patients and age-matched controls. Values in post mortem brain tissue, unlike those in spinal fluid, showed considerable variability among subjects. In the control group, frontal cortex and caudate nucleus had higher concentrations of quinolinic acid compared to other regions studied. No significant differences were found between Alzheimer brains and controls in any of the regions analyzed. Studies in lumbar spinal fluid showed no gradient for quinolinic acid along the neuraxis, a trend for increasing levels with normal aging, and no difference between Alzheimer patients and age-matched control subjects. The lack of increased central quinolinic acid levels in Alzheimer's disease does not necessarily negate the possibility of excitotoxins contributing to cell death in this disorder.
M M Mourdian; M P Heyes; J B Pan; I J Heuser; S P Markey; T N Chase; M M Mouradian
Related Documents :
10586966 - The effect of lumbar puncture stress on dopamine and serotonin metabolites in human cer...
11166796 - Defective metabolism of leukotriene b4 in the sjögren-larsson syndrome.
4687786 - Amine metabolites in human cerebrospinal fluid: effects of cord transection and spinal ...
2421656 - Dementias, psychological tests, and neurotransmitters.
16555946 - Vascular metabolic dysfunction and lipotoxicity.
8825526 - Effects of chlorotrifluoroethylene oligomer fatty acids on recombinant gaba receptors e...
Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  Neuroscience letters     Volume:  105     ISSN:  0304-3940     ISO Abbreviation:  Neurosci. Lett.     Publication Date:  1989 Oct 
Date Detail:
Created Date:  1990-12-06     Completed Date:  1990-12-06     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7600130     Medline TA:  Neurosci Lett     Country:  IRELAND    
Other Details:
Languages:  eng     Pagination:  233-8     Citation Subset:  IM    
Experimental Therapeutics Branch, National Institute of Neurological Disorders and Stroke, Bethesda, MD 20892.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Aged, 80 and over
Alzheimer Disease / metabolism*,  psychology
Brain / metabolism*
Middle Aged
Quinolinic Acid
Quinolinic Acids / cerebrospinal fluid,  metabolism*
Reg. No./Substance:
0/Quinolinic Acids; 89-00-9/Quinolinic Acid
Erratum In:
Neurosci Lett 1990 Jan 1;108(1-2):355

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Inhibition and dissociation of [3H]-paroxetine binding to human platelets.
Next Document:  Selective birth in a dyzygotic twin pregnancy with discordancy for Down's syndrome.