Document Detail


No changes in central quinolinic acid levels in Alzheimer's disease.
MedLine Citation:
PMID:  2535006     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Levels of the endogenous excitotoxin quinolinic acid were measured in brain and lumbar spinal fluid from Alzheimer patients and age-matched controls. Values in post mortem brain tissue, unlike those in spinal fluid, showed considerable variability among subjects. In the control group, frontal cortex and caudate nucleus had higher concentrations of quinolinic acid compared to other regions studied. No significant differences were found between Alzheimer brains and controls in any of the regions analyzed. Studies in lumbar spinal fluid showed no gradient for quinolinic acid along the neuraxis, a trend for increasing levels with normal aging, and no difference between Alzheimer patients and age-matched control subjects. The lack of increased central quinolinic acid levels in Alzheimer's disease does not necessarily negate the possibility of excitotoxins contributing to cell death in this disorder.
Authors:
M M Mourdian; M P Heyes; J B Pan; I J Heuser; S P Markey; T N Chase; M M Mouradian
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Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  Neuroscience letters     Volume:  105     ISSN:  0304-3940     ISO Abbreviation:  Neurosci. Lett.     Publication Date:  1989 Oct 
Date Detail:
Created Date:  1990-12-06     Completed Date:  1990-12-06     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7600130     Medline TA:  Neurosci Lett     Country:  IRELAND    
Other Details:
Languages:  eng     Pagination:  233-8     Citation Subset:  IM    
Affiliation:
Experimental Therapeutics Branch, National Institute of Neurological Disorders and Stroke, Bethesda, MD 20892.
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MeSH Terms
Descriptor/Qualifier:
Aged
Aged, 80 and over
Alzheimer Disease / metabolism*,  psychology
Brain / metabolism*
Humans
Middle Aged
Quinolinic Acid
Quinolinic Acids / cerebrospinal fluid,  metabolism*
Chemical
Reg. No./Substance:
0/Quinolinic Acids; 89-00-9/Quinolinic Acid
Comments/Corrections
Erratum In:
Neurosci Lett 1990 Jan 1;108(1-2):355

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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