| No cardiovascular effects of single-dose pseudoephedrine in patients with essential hypertension treated with beta-blockers. | |
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MedLine Citation:
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PMID: 10424315 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: The use of the decongestant pseudoephedrine has been cautioned in patients with arterial hypertension, due to the possible rise in blood pressure induced by the sympathostimulatory properties of the drug. This effect could be enhanced in hypertensives treated with beta-blockers, in whom the vasoconstrictor effect of alpha-adrenergic stimulation is unbalanced. The purpose of this study was to investigate the cardiovascular response to pseudoephedrine in hypertensive patients treated with different types of beta-blockers. METHODS: We recruited 29 (18 males) mild-to-moderate essential hypertensive patients [mean age 49(2) years] in a randomized, placebo-controlled, crossover trial. All participants received either placebo, or a nonselective (propranolol 160 mg once daily) or a selective (atenolol 100 mg once daily) beta-blocker for 1 week. At the end of each period, all patients received a single oral dose of pseudoephedrine (60 mg) and their blood pressure and heart rate were monitored at repeated intervals for 2 h. RESULTS: After 1 week of propranolol or atenolol, patients had significantly lower systolic blood pressure and heart rate than after placebo, whereas diastolic blood pressure was not significantly modified. The acute administration of pseudoephedrine did not change systolic and diastolic blood pressure and heart rate from baseline at the end of any of the treatment periods. CONCLUSIONS: A standard oral dose of pseudoephedrine does not significantly affect blood pressure values in hypertensive patients treated with beta-blockers, and therefore may be safely used in this subset of patients. |
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Authors:
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N Mores; U Campia; P Navarra; C Cardillo; P Preziosi |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: European journal of clinical pharmacology Volume: 55 ISSN: 0031-6970 ISO Abbreviation: Eur. J. Clin. Pharmacol. Publication Date: 1999 Jun |
Date Detail:
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Created Date: 1999-09-08 Completed Date: 1999-09-08 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 1256165 Medline TA: Eur J Clin Pharmacol Country: GERMANY |
Other Details:
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Languages: eng Pagination: 251-4 Citation Subset: IM |
Affiliation:
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Istituto di Farmacologia, Università Cattolica del Sacro Cuore, Rome, Italy. nmores@yahoo.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adrenergic alpha-Agonists
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adverse effects*,
therapeutic use Adrenergic beta-Antagonists / adverse effects*, therapeutic use Antihypertensive Agents / adverse effects*, therapeutic use Blood Pressure / drug effects Cross-Over Studies Ephedrine / adverse effects*, therapeutic use Female Heart Rate / drug effects Hemodynamics / drug effects* Humans Hypertension / drug therapy*, physiopathology Male Middle Aged Single-Blind Method Vasoconstrictor Agents / adverse effects*, therapeutic use |
| Chemical | |
Reg. No./Substance:
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0/Adrenergic alpha-Agonists; 0/Adrenergic beta-Antagonists; 0/Antihypertensive Agents; 0/Vasoconstrictor Agents; 299-42-3/Ephedrine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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