| No association found between the Ala54Thr polymorphism of FABP2 gene and obesity and obesity with dyslipidemia in Japanese schoolchildren. | |
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MedLine Citation:
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PMID: 11866034 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To investigate whether the Ala54Thr polymorphism of the fatty acid binding protein 2 gene is associated with obesity and obesity with dyslipidemia in Japanese schoolchildren, we analyzed 370 children with morbid obesity and 463 control children of normal weight. The allele frequencies did not differ significantly between the control group and the morbidly obese group. The odds ratio (95% confidence interval CI) in obesity of the The54 allele was 1.0 (0.9-1.3). There were no significant differences in obesity index and metabolic characteristics between the two groups. The odds ratio (95% CI) in dyslipidemia of the Thr54 allele was 1.1 (0.8-1.4) in the morbidly obese group. Our data suggested that Ala54Thr polymorphism of the FABP2 gene is not a major contributing factor for obesity and obesity with dyslipidemia in Japanese children. |
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Authors:
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K Endo; H Yanagi; C Hirano; Y Hayakawa; H Hamaguchi; S Tomura |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of atherosclerosis and thrombosis Volume: 8 ISSN: 1340-3478 ISO Abbreviation: J. Atheroscler. Thromb. Publication Date: 2001 |
Date Detail:
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Created Date: 2002-02-27 Completed Date: 2002-08-20 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9506298 Medline TA: J Atheroscler Thromb Country: Japan |
Other Details:
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Languages: eng Pagination: 80-3 Citation Subset: IM |
Affiliation:
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Institute of Community Medicine, University of Tsukuba, Ibaraki, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Alanine / genetics* Base Sequence Carrier Proteins / genetics* Child DNA Primers Fatty Acid-Binding Proteins Female Humans Hyperlipidemias / complications, ethnology, genetics* Japan Male Neoplasm Proteins* Obesity / complications, ethnology, genetics* Polymorphism, Genetic* Threonine / genetics* Tumor Suppressor Proteins* |
| Chemical | |
Reg. No./Substance:
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0/Carrier Proteins; 0/DNA Primers; 0/FABP2 protein, human; 0/FABP7 protein, human; 0/Fabp2 protein, mouse; 0/Fatty Acid-Binding Proteins; 0/Neoplasm Proteins; 0/Tumor Suppressor Proteins; 56-41-7/Alanine; 72-19-5/Threonine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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