Document Detail


No association found between the insertion/deletion of a 287-bp alu repeat sequence within intron 16 of the angiotensin-I-converting enzyme (ACE) gene in Mexican patients and binary restenosis after coronary stenting.
MedLine Citation:
PMID:  18706898     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: It has been suggested that the incidence of coronary restenosis after a percutaneous coronary intervention is much higher in patients with a 287-bp alu repeat sequence within intron 16 of the angiotensin-I-converting enzyme (ACE) gene (deletion allele) than in others, but published studies are conflicting. METHODS: The presence (insertion) or absence (deletion) of a 287-bp alu repeat sequence within intron 16 of the ACE gene (I/D polymorphism) was analyzed by polymerase chain reaction in a group of 168 patients with coronary artery disease who underwent coronary artery stenting. Basal and procedure coronary angiographies were analyzed searching for angiographic predictors of restenosis and follow-up angiography was analyzed looking for binary restenosis. RESULTS: Distribution of angiotensin converting enzyme I/D polymorphisms was similar in patients with and without restenosis. Similar results were observed when the analysis was made considering the type of stent implanted. On the other hand, the whole group of coronary artery disease patients showed increased frequencies of the D allele (p=0.00001, OR=2.17, 95% CI=1.49-3.16) and ID genotype (p=0.0002, OR=2.58, 95%CI=1.49-4.47) when compared to healthy controls. CONCLUSIONS: Genetic variations of the ACE gene could be a genetic factor related to coronary artery disease in the Mexican mixed racial ancestry individuals, but do not support its role as a risk factor for developing restenosis after coronary stenting.
Authors:
Marco Antonio Martínez-Ríos; Marco Antonio Peña-Duque; José Manuel Fragoso; Hilda Delgadillo-Rodríguez; Nonanzit Pérez-Hernández; Emma Miranda-Malpica; José Manuel Rodríguez-Pérez; Carlos González-Quesada; Gilberto Vargas-Alarcón
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-07-25
Journal Detail:
Title:  Clinica chimica acta; international journal of clinical chemistry     Volume:  397     ISSN:  0009-8981     ISO Abbreviation:  Clin. Chim. Acta     Publication Date:  2008 Nov 
Date Detail:
Created Date:  2008-09-15     Completed Date:  2009-04-17     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  1302422     Medline TA:  Clin Chim Acta     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  65-7     Citation Subset:  IM    
Affiliation:
Interventional Cardiology, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico.
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MeSH Terms
Descriptor/Qualifier:
Aged
Alleles
Alu Elements / genetics*
Coronary Angiography
Coronary Restenosis / genetics*
Female
Gene Frequency
Genotype
Heart
Humans
INDEL Mutation*
Introns / genetics
Male
Mexico
Middle Aged
Peptidyl-Dipeptidase A / genetics*
Polymorphism, Genetic
Chemical
Reg. No./Substance:
EC 3.4.15.1/Peptidyl-Dipeptidase A

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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