Document Detail

No association between a transcription factor Activating Protein 2beta (AP-2beta) gene variant and schizophrenia.
MedLine Citation:
PMID:  12270648     Owner:  NLM     Status:  MEDLINE    
Genetic components are involved in the aetiology of schizophrenia. Activating Protein 2 (AP-2) transcription factors are essential for neural gene expression and neural development. Transcription factor AP-2beta has also been connected with monoaminergic genes and monoamine levels in various brain regions. Thus, the AP-2beta gene is a suitable candidate taking both the neurodevelopmental and dopamine hypotheses of schizophrenia into account. We investigated 135 schizophrenic patients and 382 control subjects with regard to an intronic AP-2beta variant without evidence of any association. We conclude that the investigated AP-2beta variant is not of major importance to schizophrenia in the investigated Swedish population.
Erik G Jönsson; Mattias Damberg; Kaj Forslund; Marja Mattila-Evenden; Gunnar Rylander; Marie Asberg; Lars Oreland; Göran C Sedvall
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Neuroscience letters     Volume:  330     ISSN:  0304-3940     ISO Abbreviation:  Neurosci. Lett.     Publication Date:  2002 Sep 
Date Detail:
Created Date:  2002-09-24     Completed Date:  2002-12-13     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7600130     Medline TA:  Neurosci Lett     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  290-2     Citation Subset:  IM    
Copyright Information:
Copyright 2002 Elsevier Science Ltd.
Department of Clinical Neuroscience, HUBIN project, Psychiatry Section, Karolinska Institute and Hospital, SE-171 76 Stockholm, Sweden.
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MeSH Terms
DNA-Binding Proteins / genetics*
European Continental Ancestry Group
Middle Aged
Polymorphism, Genetic
Schizophrenia / genetics*
Transcription Factor AP-2
Transcription Factors / genetics*
Reg. No./Substance:
0/DNA-Binding Proteins; 0/TFAP2B protein, human; 0/Transcription Factor AP-2; 0/Transcription Factors

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