Document Detail

No association between serotonin 5-HT 1A receptors and spirituality among patients with major depressive disorders or healthy volunteers.
MedLine Citation:
PMID:  19935737     Owner:  NLM     Status:  MEDLINE    
An earlier study (Borg et al., Am J Psychiatry 2003) found an inverse correlation between [carbonyl-(11)C]WAY-100635 ligand binding to 5-HT(1A) receptors and scores for self-transcendence, but no other of the six dimensions of the Temperament and Character Inventory, in a group of healthy males. The aim of this study was to investigate if the finding of an inverse correlation between spirituality and 5-HT(1A) could be seen in patients suffering from major depressive disorder or replicated among healthy volunteers. A total of 23 patients with major depressive disorder and 20 healthy volunteers were examined with PET using [carbonyl-(11)C]WAY-100635 as the radioligand. The personality traits were measured using the Finnish version of the Temperament and Character Inventory and correlated with ligand binding (BP). No significant correlations were found between the different Temperament and Character Inventory subscales and BP in any of the studied brain regions (amygdala, anterior cingulate cortex, dorsal raphe nuclei, dorsolateral prefrontal cortex, angular gyrus, inferior, middle, and superior temporal gyri, medial prefrontal cortex orbitofrontal cortex, hippocampus, insular cortex, subgenual anterior cingulate cortex, supramarginal gyrus, ventrolateral prefrontal cortex, and posterior cingulate cortex). These results do not support the idea that the serotonin system forms the biological basis of spiritual experiences among patients suffering from major depressive disorder or among healthy volunteers.
H Karlsson; J Hirvonen; J K Salminen; J Hietala
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-11-24
Journal Detail:
Title:  Molecular psychiatry     Volume:  16     ISSN:  1476-5578     ISO Abbreviation:  Mol. Psychiatry     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-02-18     Completed Date:  2011-06-03     Revised Date:  2012-05-07    
Medline Journal Info:
Nlm Unique ID:  9607835     Medline TA:  Mol Psychiatry     Country:  England    
Other Details:
Languages:  eng     Pagination:  282-5     Citation Subset:  IM    
Department of Psychiatry, University of Helsinki, Turku, Finland.
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MeSH Terms
Brain / drug effects,  pathology*,  radionuclide imaging
Carbon Isotopes / pharmacokinetics
Depressive Disorder, Major / metabolism*,  pathology,  psychology,  radionuclide imaging
Middle Aged
Piperazines / pharmacokinetics
Positron-Emission Tomography / methods
Radioligand Assay / methods
Receptor, Serotonin, 5-HT1A / metabolism*
Serotonin 5-HT1 Receptor Antagonists / pharmacokinetics
Statistics as Topic
Reg. No./Substance:
0/Carbon Isotopes; 0/Piperazines; 0/Serotonin 5-HT1 Receptor Antagonists; 112692-38-3/Receptor, Serotonin, 5-HT1A; 133025-23-7/WAY 100135
Erratum In:
Mol Psychiatry. 2012 Apr;17(4):467

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