Document Detail

No association between early gastrointestinal problems and autistic-like traits in the general population.
MedLine Citation:
PMID:  21418197     Owner:  NLM     Status:  MEDLINE    
AIM: The aim of this study was to determine whether gastrointestinal problems in early childhood relate to autistic-like traits in a general population sample.
METHOD: The parents of 804 children (442 females; 362 males) reported at 1-, 2-, 3-, and 5-year follow-ups whether their child had been taken to a hospital, general practitioner, or health clinic for any of five gastrointestinal symptoms: (1) constipation; (2) diarrhoea; (3) abdominal bloating, discomfort, or irritability; (4) gastro-oesophageal reflux or vomiting; and (5) feeding issues or food selectivity. Parents also reported whether their child had received the measles, mumps, and rubella vaccination. Autistic-like traits were measured when the children had reached early adulthood (mean age 19 y 7 mo; SD 0.63 y) using a self-report questionnaire, the Autism Spectrum Quotient (AQ).
RESULTS: There was no statistically significant difference in AQ scores between those who had (n=133) and those who had not (n=671) experienced early gastrointestinal symptoms. χ(2) analyses revealed that the children with early gastrointestinal problems were no more likely to be represented in the upper quintile of scores on any of the AQ scales. The measles, mumps, and rubella vaccination was unrelated to gastrointestinal symptoms or AQ scores.
INTERPRETATION: Parent-reported gastrointestinal problems in early childhood are unrelated to self-reported autistic-like traits in the general population.
Andrew J O Whitehouse; Murray Maybery; John A Wray; Martha Hickey
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2011-03-21
Journal Detail:
Title:  Developmental medicine and child neurology     Volume:  53     ISSN:  1469-8749     ISO Abbreviation:  Dev Med Child Neurol     Publication Date:  2011 May 
Date Detail:
Created Date:  2011-04-12     Completed Date:  2011-06-10     Revised Date:  2011-10-21    
Medline Journal Info:
Nlm Unique ID:  0006761     Medline TA:  Dev Med Child Neurol     Country:  England    
Other Details:
Languages:  eng     Pagination:  457-62     Citation Subset:  IM    
Copyright Information:
© The Authors. Developmental Medicine & Child Neurology © 2011 Mac Keith Press.
Telethon Institute for Child Health Research, Centre for Child Health Research, University of Western Australia, Crawley, WA, Australia.
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MeSH Terms
Age Factors
Autistic Disorder / complications*,  etiology
Child, Preschool
Follow-Up Studies
Gastrointestinal Diseases / etiology*
Retrospective Studies
Vaccination / adverse effects,  methods
Young Adult

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